| Granzyme B | IFNγ | TNFα |
---|
| CD8 + NKT-like | NK | CD8 + NKT-like | NK | CD8 + NKT-like | NK |
---|
| 28- | 28+ | | 28- | 28+ | | 28- | 28- | |
---|
a137
|
21 ± 2* |
14 ± 2 |
14 ± 2 |
26 ± 3* |
20 ± 3 |
22 ± 3 |
30* ± 4 |
23* ± 4 |
24 ± 3 |
MP
|
1 ± 1 |
3 ± 2 |
2 ± 2 |
2 ± 1 |
5 ± 6 |
43 ± 3^ |
2 ± 1 |
2 ± 1 |
47 ± 9^ |
a137 + MP
|
22 ± 4#
|
17 ± 3#
|
15 ± 3#
|
28 ± 3#
|
25 ± 2#
|
66 ± 3 |
32 ± 4#
|
25 ± 4#
|
70 ± 7#
|
- *The percentage inhibition of granzyme B, IFNγ and TNFα by CD28- and CD28+ NKT-like and NK cells compared with control (same specimen) without treatment/s.
- The inhibitory effect of anti-CD137 was greater than for MP for granzyme B, IFNγ and TNFα in all NKT-like cell subsets (p < 0.05 for all).
- *The inhibitory effect of anti-CD137 was greater than for the CD28nullCD8+ NKT-like subset than for the CD28 + CD8+ NKT-like subset for granzyme B, IFNγ and TNFα (p < 0.05 for all). ^The inhibitory effect of MP on IFNγ and TNFα by NK cells was significantly greater than for Granzyme B (p < 0.05) and significantly greater than the effect of anti-CD137.
-
#The combination of anti-CD137 and 10-6 M methylprednisolone resulted in the additive inhibition of granzyme B, IFNγ and TNFα expression in CD28null and CD28+ CD8+ NKT-like cells and NK cells.