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Table 3 Comparison between idiopathic pleuroparenchymal fibroelastosis (IPPFE) and idiopathic pulmonary fibrosis (IPF): findings on high resolution computed tomography (HRCT) and lung specimens

From: Quantitative analysis of lung elastic fibers in idiopathic pleuroparenchymal fibroelastosis (IPPFE): comparison of clinical, radiological, and pathological findings with those of idiopathic pulmonary fibrosis (IPF)

 

IPPFE (n = 6)

IPF (n = 28)

p value

Findings on HRCT

   

 Extent score, 0-25

9.8 ± 2.6

8.8 ± 3.7

0.366

 Upper lobe predominant distribution, n (%)

6 (100)

0 (0)

<0.0001*

 Reticulation score, 0-3

1.3 ± 0.5

1.8 ± 0.7

0.161

 Glass score, 0-3

1.5 ± 0.8

1.7 ± 0.7

0.429

 Consolidation score, 0-3

1.7 ± 0.8

0.3 ± 0.5

0.004

 Existence of honeycombing, n (%)

0 (0)

10 (35.7)

0.148*

 Emphysema score, 0-3

0

0.7 ± 0.9

0.078

 Pleural thickening, n (%)

6 (100)

2 (7.1)

<0.0001*

Findings on surgical lung biopsy specimens

   

 Collagen deposition score, 0-3

2.0 ± 0

2.4 ± 0.8

0.175

 Existence of microscopic honeycombing, n (%)

1 (16.7)

17 (60.7)

0.078*

 Organizing pneumonia score, 0-3

1.8 ± 0.4

0.6 ± 0.7

0.003

 Cellularity score in interstitium, 0-3

1.5 ± 0.5

1.3 ± 0.6

0.456

 Lymphoid hyperplasia, n (%)

0 (0)

0 (0)

NA.

 Pleural fibrosis, pleuritis, n (%)

5 (83.3)

0 (0)

<0.0001*

  1. Data are presented as mean ± SD or, n (%).
  2. Data are analysed with Mann-Whitney’s U-test or *Fisher’s exact probability test.
  3. HRCT high resolution computed tomography, NA not applicable.