Table 4 Spirometry, Shwachman-Kulczycki scores, and prevalence of F508del mutation in patients with cystic fibrosis in a Brazilian referral center during the decades of 1990 to 2000 and 2000 to 2010
Decade | Spirometry | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|
ORD | OR (95% CI) | MRD | OR (95% CI) | RVD | OR (95% CI) | Normal | OR (95% CI) | ||
1990–2000 | 14 (25.0%) | 2.058 (0.87–4.79) | 16 (29.8%) | 17.58 (4.70–98.97) | 10 (18.3%) | 0.231 (0.10–0.51) | 15 (26.9%) | 0.719 (0.33–1.50) | 55 |
2000–2010 | 19 (14.2%) | 1 | 3 (2.2%) | 1 | 66 (49.3%) | 1 | 46 (34.3%) | 1 | 134 |
Decade | Clinical score | Total | |||||||
| Â | Moderate/Severe | OR (95% CI) | Mild | OR (95% CI) | Excellent/Good | OR (95% CI) | Â | ||
1990–2000 | 13 (15.4%) | 0.491 (0.24–0.96) | 22 (26.9%) | 0.635 (0.34–1.18) | 48 (57.7%) | 2.403 (1.40–4.16) | 83 | ||
2000–2010 | 44 (27.5%) | 1 | 58 (36.3%) | 1 | 58 (36.3%) | 1 | 160 | ||
Decade | F508del mutation genotype | Total | |||||||
| Â | Homozygotes | OR (95% CI) | Heterozygotes | OR (95% CI) | Without F508del | OR (95% CI) | Â | ||
1990–2000 | 19 (20.2%) | 0.647 (0.34–1.21) | 59 (61.5%) | 5.445 (3.09–9.74) | 18 (18.3%) | 0.235 (0.13–0.42) | 96 | ||
2000–2010 | 50 (27.6%) | 1 | 41 (22.7%) | 1 | 90 (49.7%) | 1 | 181 | ||