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Table 4 Multivariate Coefficients (sd) for Rate of loss of Actual FEV1 (after allowance for regression to the mean)

From: The Darlington and Northallerton Long Term Asthma Study: pulmonary function

   Age Excluded Age Included
   Coefficient p Coefficient p
Gender (male v female) 5.5 (4.8) 0.25 5.7 (4.7) 0.23
Asthma since childhood 13.5 + (5.1) 0.008 4.9+ (5.8) 0.40
Social Classes 1 & 2 (v. classes 4 & 5) 4.8 (5.4) 0.65 1.8 (5.4) 0.88
Social Class 3 (v. classes 4 & 5) 1.1 (5.1)   0.6+ (5.0)  
Amount smoked (per 10 pack years) 1.8 (1.2) 0.13 1.0 (1.2) 0.39
Best PEF(per 10% deficit) 1.2+ (1.2) 0.33 0.9+ (1.2) 0.41
Actual/Best PEF(10% deficit) 12.0 + (1.6) <0.0001 13.2 + (1.6) <0.0001
Age at entry (per decade) (difference from age 50) Linear    3.5+ (3.1)  
  quadratic    4.9+ (0.9)  
  cubic    1.2 (0.6) 0.02
Duration of asthma at entry (per decade) (difference from duration 20 yrs) Linear 1.3 (2.8)   2.0+ (2.4)  
  quadratic 3.2 (1.5)   0.9 (0.5)  
  cubic 0.85 + (0.38) 0.03 2.5+ (0.39) 0.52
  1. (+) Indicates relative gain in function