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Table 5 Multivariate Coefficients for loss of Best FEV1 (after allowance for regression to the mean)

From: The Darlington and Northallerton Long Term Asthma Study: pulmonary function

   Age Excluded Age Included
   Coefficient (sd) p Coefficient (sd) p
Gender (male v female) 11.3 (5.1) 0.03 11.9 (5.4) 0.02
Asthma since childhood 5.1+ (5.3) 0.34 1.1+ (6.0) 0.86
Social Classes 1 & 2 (v. classes 4 & 5) 13. (5.7) 0.05 10.7 (5.6) 0.11
Social Class 3 (v. classes 4 & 5) 2.9 (5.3)   1.4 (5.2)  
Amount smoked (per 10 pack years) 0.7 (1.3) 0.60 0.5 (1.3) 0.71
Best PEF(per 10% deficit) 3.4 + (1.3) 0.008 3.1 + (1,2) 0.01
Actual/Best PEF(10% deficit) 0.7+ (1.8) 0.71 1.4+ (1.8) 0.44
Age at entry (per decade) (difference from age 50) Linear    8.4+(3.2)  
  quadratic    5.1+ (0.9)  
  cubic    1.8 (0.5) 0.0003
Duration of asthma at entry (per decade) (difference from duration 20 yrs) Linear 3.1 (2.4)   0.2 (2.4)  
  quadratic 2.5 (1.6)   0.4 (1.6)  
  cubic 0.91 + (0.39) 0.02 0.29+ (0.40) 0.46
  1. (+) Indicates relative gain in function