Source | Number of Patients | Age (year) | Men (%) | Current Smokers (%) | Pack-years | FEV1 (% predicted) | Ratio (%) | Reversibility (% predicted) | Drug | Dose (mg/day) | Duration (weeks) | Cumulative dose (mg) # |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sugiura [7] | 18‡ | 70(7) | 89 | 0* | NR | 1.2(0.4)†| <70 | <12 | Beclomethasone | 0.8 | 4 | 22.4 |
Keatings [18] | 26 | 45–78 | 60 | 46 | >10 | 35.1(4.7) | <70 | <10 | Budesonide | 1.6 | 2 | 28.0 |
Culpitt [19] | 26 | 43–73 | 62 | 69 | >20 | 49.5(16.6) | <70 | <15 | Fluticasone | 1.0 | 4 | 56.0 |
Confalonieri [20] | 34 | 58 (5) | 59 | 100 | NR | 59.7(37.1) | 67 (5) | NR | Beclomethasone | 1.5 | 8 | 84.0 |
Mirici [21] | 40 | 53(10) | 75 | 100 | 26.5 (16.1) | 62.0(7.4) | NR | <15 | Budesonide | 0.8 | 12 | 84.0 |
Yildiz [22] | 18 | 64(7) | 78 | 89 | 52.0 (23.4) | 44.5(2.7) | 57 (3) | <10 | Fluticasone | 1.5 | 8 | 168.0 |