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Table 1 Maximal contractile responses after DSP or nicotine incubation. The maximal contractile responses (% of maximal contraction to 60 mM potassium) and pEC50 of endothelin-1 and sarafotoxin 6c in bronchial segments from 24 hour DSP or nicotine incubation as compared with control segments The values are given as means ± S.E.M., n = 6–10. Unpaired t-tests were used to compare the groups in terms of maximum induced contraction; #* P < 0.05.

From: Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi

Rat Bronchi
  Maximal contraction pEC50
Endothelin-1
Control 121.21 ± 4.84# 7.69 ± 0.49
DSP 154.24 ± 14.88# 7.43 ± 0.35
Nicotine 106.49 ± 7.53 7.39 ± 0.13
Sarafotoxin6c
Control 144.25 ± 4,01* 8.24 ± 0.08
DSP 213.39 ± 20.03* 8.21 ± 0.17
Nicotine 135.01 ± 11.25 8.24 ± 0.35