Skip to main content

Table 1 Maximal contractile responses after DSP or nicotine incubation. The maximal contractile responses (% of maximal contraction to 60 mM potassium) and pEC50 of endothelin-1 and sarafotoxin 6c in bronchial segments from 24 hour DSP or nicotine incubation as compared with control segments The values are given as means ± S.E.M., n = 6–10. Unpaired t-tests were used to compare the groups in terms of maximum induced contraction; #* P < 0.05.

From: Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi

Rat Bronchi

 

Maximal contraction

pEC50

Endothelin-1

Control

121.21 ± 4.84#

7.69 ± 0.49

DSP

154.24 ± 14.88#

7.43 ± 0.35

Nicotine

106.49 ± 7.53

7.39 ± 0.13

Sarafotoxin6c

Control

144.25 ± 4,01*

8.24 ± 0.08

DSP

213.39 ± 20.03*

8.21 ± 0.17

Nicotine

135.01 ± 11.25

8.24 ± 0.35