Impact on patient well-being. Frequency of symptoms and disruption of sleep and activities caused by comorbid asthma and allergic rhinitis, by region (a) and by age group (b). *P ≤ 0.05 for comparison between Europe and the Asia-Pacific region or between adults and children. For symptoms, a positive response was defined as symptoms occurring all of the time, a lot of the time, or some of the time. Disruption was defined as occurring a great deal, quite a lot, or a little bit.