Skip to main content

Table 10 Covariate variable derivations

From: Design of the Endobronchial Valve for Emphysema Palliation Trial (VENT): a non-surgical method of lung volume reduction

Variable

Definition

RV

Residual Volume by Spirometry and Plethysmography (TLC - Max (FVC or VC))

TLC

Total Lung Capacity by Plethysmography

VC

Vital Capacity by Plethysmography

FVC

Forced Vital Capacity by Spirometry

FEV1

Forced Expiratory Volume in the First Second by Spirometry

Target Lobe

RUL, RLL, LUL, or LLL

RUL

RUL Target vs. Others

Density Score

Density Score by Lobe

Total Density Score

Sum of all Lobar Density Scores (including RML)

Ipsilateral DS Heterogeneity

Target - Max DS of Non-treated Lobes within Treated Lung [e.g.: RUL - Max(RML, RLL)]

Thorax DS Heterogeneity

Target DS - Max DS of All Non-treated Lobes [e.g.: RUL - MAX (RML, RLL, LUL, LLL)]

Target Lobe DS % Delta

(TLC HRCT - RV HRCT)/TLC HRCT Density Score of Target Lobe

Target Lobe Volume % Delta

(TLC HRCT Volume - RV HRCT)/TLC HRCT Volume of Target Lobe

Fissure Score

Categorical Fissure Assessment Surrounding Target Lobe

 

1 = Absent

 

2 = Incomplete

 

3 = Complete

NETT Strata

1 = Upper-Lobe Predominance, Low Baseline Exercise Capacity*

 

2 = Upper-Lobe Predominance, High Baseline Exercise Capacity

 

3 = Non-Upper-Lobe Predominance, Low Baseline Exercise Capacity

 

4 = Non-Upper-Lobe Predominance, High Baseline Exercise Capacity

Target Lobe Atelectasis Scores

% change in Target Lobe Volume at TLC and at RV between Baseline and 180-day HRCT

Lobar Exclusion

Yes, If all bronchial pathways to target lobe are sealed by valve(s) – adjudicated by HRCT Core Lab

Valve Combinations

1. Small ONLY

 

2. Small AND Large

 

3. Large Only

Large Valve

Any procedure with Only Large Valves vs. all others

Small Valve

Any procedure with Only Small Valves vs. all others

  1. *Low Exercise Capacity by Cycle Ergometry ≤ 25 W for Women, ≤ 40 W for Men