Design of the Endobronchial Valve for Emphysema Palliation Trial (VENT): a non-surgical method of lung volume reduction

Table 6 Plethysmography, spirometry and HRCT derived baseline potential covariates*

Variable	Plethysmography/Spirometry	HRCT at TLC	HRCT at RV	TLC and RV HRCT ^†
RV	X
RV % Predicted	X
TLC	X
TLC % Predicted	X
RV/TLC	X
VC	X
FVC	X
FVC % Predicted	X
FEV₁	X
FEV₁ % Predicted	X
FEV₁/FVC	X
Destruction Score of Target Lobe		X	X
Ipsilateral Heterogeneity^††		X	X
Whole Lung Heterogeneity^††		X	X
For RUL Treatment Subset only: RUL-RML Heterogeneity^††		X	X
Target Lobe Volume % of TLC		X
Target Lobe Volume % of RV			X
Max Destruction Score other than target		X	X
Min Destruction Score other than target		X	X
Target Lobe Destruction Score % TLC-RV Delta				X
Target Lobe Volume % TLC-RV Delta				X
Fissure Score^†††		X

*Variables marked in multiple columns will be calculated twice, once using the expiratory (RV) CT and once using the inspiratory (TLC) CT. All tests are at Baseline.
^†Some variables require information from both the TLC and RV CT
^†† Heterogeneity scores are derived by subtracting the minimum destruction score from the maximum destruction score.
^††† Fissure Score is an integer scale from one to three base on visual scoring by core center radiologists (1 = Fissure Absent, 2 = Incomplete Fissure, 3 = Complete Fissure).

ISSN: 1471-2466