Table 8 Composite or other potential covariate interactions

Baseline BODE

BMI, FEV₁% predicted, MMRC, 6 MWT Composite Score

NETT Strata

Randomization Stratification by Baseline Cycle Ergometry and HRCT at TLC

NETT Strata by Right vs. Left

Randomization Stratification by Baseline Cycle Ergometry and HRCT at TLC, by Right or Left Lung

Lobar Exclusion by Fissure Interaction*

Fissure Score = 3 AND Lobar Exclusion = Yes vs. all others

Lobar Exclusion, Fissure, and RV % Predicted*

Lobar Exclusion = Yes AND Fissure Score = 3 AND RV % Predicted ≥ 200% vs. all others

Lobar Exclusion, Fissure, and RV % Predicted*

Lobar Exclusion = Yes AND Fissure Score = 3 AND RV % Predicted ≥ 200% vs. all others

Large Valve by Right vs. Left*

Right vs. Left Lung AND Large Only vs. Others

Small Valve by Right vs. Left*

Right vs. Left Lung AND Small Only vs. Others

Expectorated Valve Replaced*

Valve(s) Expectorated AND Lobar Exclusion = Yes vs. all others

Expectorated Valve Not Replaced*

Valve(s) Expectorated AND Lobar Exclusion = No vs. all others

Lobar Exclusion by Site*

Technical Success by Site

First Case by Site*

First Treatment Case by Site vs. All Others

Learning Curve by Site*

Experience Level: Case 1, vs. 2 & 3, vs. 4–6, vs. 7–9, vs. ≥10 by site.