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Table 4 Association between the changes in serum protein biomarkers, lung function, dyspnea score and total CRQ scores over 3 months

From: Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study

  Change in SPD* Change in CC16* Change in CRP* Change in distance
  β R P β R P β R P β R P
Change in Dyspnea Score -1.95 (-1.95) 0.56 (0.56) 0.018 (0.018) -1.33 (-1.55) 0.24 (0.28) 0.359 (0.185) 0.42 (0.19) 0.23 (0.10) 0.367 (0.626) -14.63 (-16.91) 0.46 (0.52) 0.063 (0.032)
Change in CRQ Score -1.50 (-1.13) 0.61 (0.44) 0.010 (0.008) -1.52 (-2.01) 0.38 (0.49) 0.135 (0.011) -0.14 (-0.35) 0.10 (0.26) 0.688 (0.214) -15.67 (-15.67) 0.36 (0.36) 0.163 (0.163)
Change in SPD*   -- -- 0.64 (0.64) 0.39 (0.39) 0.119 (0.119) 0.15 (0.15) 0.29 (0.08) 0.261 (0.261) 3.05 (3.05) 0.03 (0.03) 0.916 (0.916)
Change in CC16*   -- --   -- -- 0.10 (0.10) 0.30 (0.30) 0.248 (0.182) 61.38 (88.51) 0.35 (0.46) 0.175 (0.611)
Change in CRP*           -5.81 (-5.81) 0.10 (0.10) 0.698 (0.698)
  1. * Logarithmic scale.
  2. † Change in the distance of six-minute walk test (m).
  3. Values in brackets were derived from a stepwise regression model in which age, sex, body mass index, PO2, PCO2 and FEV1 were included in the model.
  4. Abbreviations: CC16 – Clara cell protein 16, CRP – C-reactive protein, CRQ – Chronic Respiratory Disease Questionnaire, SPD – surfactant protein D.