Table 4 Differences in lung function measurements and prevalence of airway obstruction according to the ETB genotype in the ECRHS population
From: ETBreceptor polymorphism is associated with airway obstruction
FEV1 (%predicted)* | FEV1/FVC* | FEV1 ≤ 80%pred | ||||
|---|---|---|---|---|---|---|
mean | (SE) | mean | (SE) | % | (n) | |
All patients (n = 632) | ||||||
AA (n = 109) | 104.8 | (1.36) | 84.2 | (0.7) | 4.6 | (5) |
AG (n = 304) | 107.0 | (0.81) | 83.4 | (0.4) | 2.0 | (6) |
GG (n = 219) | 104.4 | (0.95) | 83.2 | (0.5) | 7.3 | (16) |
p | 0.09 | 0.47 | 0.012 | |||
AG+AA (n = 413) | 106.4 | (0.70) | 83.6 | (0.3) | 2.7 | (11) |
GG (n = 219) | 104.4 | (0.96) | 83.2 | (0.5) | 7.3 | (16) |
p | 0.09 | 0.55 | 0.005 | |||
Never smokers (n = 269) | ||||||
AG+AA (n = 170) | 107.4. | (1.1) | 84.3 | (0.5) | 0.6 | (1) |
GG (n = 99) | 105.9 | (1.4) | 83.6 | (0.7) | 7.1 | (7) |
p | 0.39 | 0.40 | -† | |||
Smokers ≥ 12 pack-Years (n = 201) | ||||||
AG+AA (n = 138) | 105.7 | (1.2) | 81.9 | (0.6) | 2.2 | (3) |
GG (n = 63) | 99.6 | (1.8) | 82.4 | (0.9) | 11.1 | (7) |
p | 0.007 | 0.6 | 0.007 | |||
Asthmatics (n = 87) | ||||||
AG+AA (n = 52) | 102.8 | (2.4) | 81.2 | (1.1) | 5.8 | (3) |
GG (n = 35) | 93.1 | (2.9) | 77.9 | (1.4) | 22.9 | (8) |
p | 0.012 | 0.07 | 0.02 | |||