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Figure 3 | BMC Pulmonary Medicine

Figure 3

From: Surfactant replacement and open lung concept – Comparison of two treatment strategies in an experimental model of neonatal ARDS

Figure 3

Histological sum scores (upper, middle and lower right lung lobe). Histologic sum scores (atelectasis, alveolar and interstitial inflammation, alveolar and interstitial hemorrhage, alveolar and interstitial edema, necrosis and overdistension) of upper, middle and lower right lung lobe using a four-point scale with no injury corresponding to 0 points and 4 points indicating maximum injury (A). Comparison of the groups showed no significant differences. Hematoxylin-eosin staining of exemplary histologic slides showing dystelectasis and neutrophiles in nearly all alveoli in the PPVOLC group (B), regularly ventilated lung parenchyma in the monomeric SP-B group (C) and dystelectasis and neutrophiles in some of the alveoli in the natural SF group (D; hematoxylin-eosin, magnification 100×). Study groups: open lung concept positive pressure ventilation (PPVOLC; n = 5); surfactant treatment under conventional positive pressure ventilation with a modified monomeric surfactant protein B surfactant (mon SP-B; n = 4) or a natural bovine surfactant (Alveofact®; nat SF; n = 4). Results are given as mean and standard deviation.

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