Mean ± SEM | p- value | ||
---|---|---|---|
MMP-8 (ng/ml) | |||
Control group (n = 18) | 24 (± 7) | HAP vs. control | 0.346 |
All HAP patients (n = 37) | 435 (± 131) | ||
HAP subgroups | |||
• Bacteria | high vs. low risk | 0.002 | |
○ high-risk bacteria (n = 17) | 750 (± 245) | high vs. control | 0.0007 |
○ low-risk bacteria (n = 20) | 167 (± 93) | low vs. control | 0.198 |
• invasive ventilation | |||
○ ventilated (n = 15) | 891 (± 266) | vent. vs. not vent. | <0.0001 |
○ not ventilated (n = 22) | 124 (± 77) | ||
MMP-9 (ng/ml) | |||
Control group (n = 18) | 50 (± 17)* | HAP vs. control | 0.059 |
All HAP patients (n = 37) | 657 (± 157)* | ||
HAP subgroups | |||
• Bacteria | high vs. low risk | <0.0001 | |
○ high-risk bacteria (n = 17) | 1168 (± 266)** | high vs. control | <0.0001 |
○ low-risk bacteria (n = 20) | 224 (± 119)** | low vs. control | 0.497 |
• invasive ventilation | |||
○ ventilated (n = 15) | 1309 (± 266)*** | vent. vs. not vent. | <0.0001 |
○ not ventilated (n = 22) | 213 (± 131)*** | ||
MMP-9 gelatinolytic activity (%) | |||
Control group (n = 18) | 34 (± 11)* | HAP vs. control | 0.0001 |
All HAP patients (n = 37) | 149 (± 41)* | ||
HAP subgroups | |||
• Bacteria | high vs. low risk | 0.0001 | |
○ high-risk bacteria (n = 17) | 325 (± 106)** | high vs. control | <0.0001 |
○ low-risk bacteria (n = 20) | 67 (± 14)** | low vs. control | 0.007 |
• invasive ventilation | |||
○ ventilated (n = 15) | 197 (± 40)*** | vent. vs. not vent. | 0.0024 |
○ not ventilated (n = 22) | 118 (± 63)*** | ||
TIMP-1 (ng/ml) | |||
Control group (n = 18) | 410 (± 80)* | HAP vs. control | 0.275 |
All HAP patients (n = 37) | 648 (± 164)* | ||
HAP subgroups | |||
• Bacteria | high vs. low risk | 0.0039 | |
○ high-risk bacteria (n = 17) | 983 (± 285)** | high vs. control | 0.290 |
○ low-risk bacteria (n = 20) | 364 (± 165)** | low vs. control | 0.005 |
• invasive ventilation | |||
○ ventilated (n = 15) | 1309 (± 261)*** | vent. vs. not vent. | <0.0001 |
○ not ventilated (n = 22) | 132 (± 40)*** | ||
MMP-9/TIMP-1 molar ratio | |||
Control group (n = 18) | 0.04 (± 0.02)* | HAP vs. control | <0.0001 |
All HAP patients (n = 37) | 0.43 (± 0.12)* | ||
HAP subgroups | |||
• Bacteria | high vs. low risk | 0.0002 | |
○ high-risk bacteria (n = 17) | 0.66 (± 0.17)** | high vs. control | <0.0001 |
○ low-risk bacteria (n = 20) | 0.24 (± 0.15)** | low vs. control | 0.0028 |
• invasive ventilation | |||
○ ventilated (n = 15) | 0.66 (± 0.23)*** | vent. vs. not vent. | 0.0046 |
○ not ventilated (n = 22) | 0.28 (± 0.12)*** |