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Figure 2 | BMC Pulmonary Medicine

Figure 2

From: Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice

Figure 2

A. Immunohistochemical reaction for macrophage Mac-3 on lung parenchyma of a C57Bl/6J mouse after a 6 month cigarette smoke exposure. B. Macrophage volume density in the lung of C57BL76J mice exposed either to room air or to cigarette smoke for 6 months and treated or not with roflumilast at 2 doses. Air = air exposure; CS = cigarette smoke exposure; R1 = treated with roflumilast at the dose 1 mg/kg po; R5 = treated with roflumilast at the dose 5 mg/kg po; N = 5 in all groups except "CS -" where N = 7, "CS +R1"where N = 6 and "CS +R5" where N = 7; * = p < 0.01 versus air exposed, ++ = < 0.01 versus smoke exposed. Scale Bar = 40 μm.

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