Figure 3
From: Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice
A. Immunohistochemical reaction for dendritic cell fascin observed perivascularly on a lung of a C57Bl/6J mouse after a 6 month cigarette smoke exposure. B. Dendritic cell volume density in the lung of C57BL76J mice exposed either to room air or to cigarette smoke for 6 months and treated or not with roflumilast at 2 doses. Air = air exposure; CS = cigarette smoke exposure; R1 = treated with roflumilast at the dose 1 mg/kg po; R5 = treated with roflumilast at the dose 5 mg/kg po; N = 5 in all groups except "CS +R1"where due to technical problems N = 3; * = p < 0.01 versus air exposed, + = < 0.05 versus smoke exposed. Scale Bar = 40 μm.