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Table 3 Abilities of top individual analytes to discriminate positive QFT results as active TB or LTBI

From: Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report

Marker Level in Pulmonary TB
(n = 22)
Level in LTBI
(n = 25)
Cut-off
(pg/ml)
Sensitivity
%
Specificity
%
PPV,
%
NPV,
%
EGF Nil 115.5
(39.1–222.2)
34.5
(15.2–214.0)
76.16 90.9 84.0 83.3 91.3
EGF Ag 65.7
(23.4–121.8)
27.2
(12.2–487.9)
46.68 81.8 88.0 85.7 84.6
EGF Ag-Nil -44.9
(-116.1–0.44)
-7.0
(-48.9–274.0)
-25.6 92.0 81.8 85.1 90.0
TGF-α Ag 22.2
(1.0–168.0)
13.4
(4.3–47.1)
13.78 81.8 60.0 64.3 78.9
IFN-γ Ag-Nil 99.3
(-216.4–699.8)
206.9
(8.7–6112.0)
106.68 80.0 54.5 66.7 70.6
sCD40L Nil 3995.0
(876.1–10245.0)
1002.0
(220.4–>20000)
2307.54 86.4 80.0 79.2 87.0
sCD40L Ag 1974.0
(883.0–13493.0)
1040.0
(383.2–>20000)
1563.66 86.4 72.0 73.1 85.7
sCD40L Ag-Nil -1502.0
(-5339.0–3496.0)
10.6
(-3527.0–3927.0)
-471.06 88.0 68.2 75.9 83.3
MIP-1β Ag-Nil 458.5
(-1035–2321.0)
1833.0
(290.0–6890.0)
836.18 84.0 63.6 72.4 77.8
VEGF Nil 83.4
(0.0–482.3)
19.5
(0.0–415.8)
72.78 63.6 84.0 77.8 72.4
  1. Median levels (pg/ml) and ranges (in parenthesis) of individual markers measured in QFT positive supernatants and abilities to discriminate between positive QFT results as either pulmonary TB or LTBI. Only markers with either sensitivity and/or specificity ≥ 80.0% between groups are shown. LTBI = household contacts with both positive QFT and TST results, PPV = positive predictive value, NPV = negative predictive. Levels shown as >20000 pg/ml were above the range of the standard curve.