Table 3 Abilities of top individual analytes to discriminate positive QFT results as active TB or LTBI
Marker | Level in Pulmonary TB (n = 22) | Level in LTBI (n = 25) | Cut-off (pg/ml) | Sensitivity % | Specificity % | PPV, % | NPV, % |
|---|---|---|---|---|---|---|---|
EGF Nil | 115.5 (39.1–222.2) | 34.5 (15.2–214.0) | 76.16 | 90.9 | 84.0 | 83.3 | 91.3 |
EGF Ag | 65.7 (23.4–121.8) | 27.2 (12.2–487.9) | 46.68 | 81.8 | 88.0 | 85.7 | 84.6 |
EGF Ag-Nil | -44.9 (-116.1–0.44) | -7.0 (-48.9–274.0) | -25.6 | 92.0 | 81.8 | 85.1 | 90.0 |
TGF-α Ag | 22.2 (1.0–168.0) | 13.4 (4.3–47.1) | 13.78 | 81.8 | 60.0 | 64.3 | 78.9 |
IFN-γ Ag-Nil | 99.3 (-216.4–699.8) | 206.9 (8.7–6112.0) | 106.68 | 80.0 | 54.5 | 66.7 | 70.6 |
sCD40L Nil | 3995.0 (876.1–10245.0) | 1002.0 (220.4–>20000) | 2307.54 | 86.4 | 80.0 | 79.2 | 87.0 |
sCD40L Ag | 1974.0 (883.0–13493.0) | 1040.0 (383.2–>20000) | 1563.66 | 86.4 | 72.0 | 73.1 | 85.7 |
sCD40L Ag-Nil | -1502.0 (-5339.0–3496.0) | 10.6 (-3527.0–3927.0) | -471.06 | 88.0 | 68.2 | 75.9 | 83.3 |
MIP-1β Ag-Nil | 458.5 (-1035–2321.0) | 1833.0 (290.0–6890.0) | 836.18 | 84.0 | 63.6 | 72.4 | 77.8 |
VEGF Nil | 83.4 (0.0–482.3) | 19.5 (0.0–415.8) | 72.78 | 63.6 | 84.0 | 77.8 | 72.4 |