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Table 1 Clinical Characteristics

From: IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis

 

Control

(n = 16)

Asthma Mild-moderate

(GINA 1 = 6, GINA 2–3 = 6)

Asthma Severe

(GINA 4 = 6, GINA 5 = 6)

Eosinophilic Bronchitis

(n = 7)

Age (yrs)~

32.2 (2.3)

37.3 (3.7)

51.0 (4.3)*

53.6 (6.2)*

Sex M:F

7:9

7:5

4:8

6:1

Atopy (%)

46

83**

67**

43

Disease Duration (yrs)

N/A

22.0 (3.8)**

30.4 (4.9)**

8.4(1.8)

BDP Equivalent (mcg)

N/A

355 (132)

1633 (175)

1149(420)

Oral Prednisolone

(mg/24 hrs)

N/A

N/A

5.6 (2.0)

0

ENO (50)

(Ppb) #

18 [9–37]

28 [19–46]

19 [14–25]

34 [18–64]

PC 20 (mg/ml)#

>16

1.4 [0.4–4.9]**

0.45 [0.1–1.7]**

>16

FEV 1 % predicted~

109 (3.3)

90 (8.7)

78 (6.0)*

95.7(5.6)

FEV 1 /FVC~

86.3(1.7)

79 (3.4)

72 (3.5)*

80.0(4.4)

Induced sputum

    

Eosinophils (%)#

0.7 [0.2–2.7]

2.2 [0.4–13.0]*

1.9 [0.8–4.6]*

4.6 [1.3–16.5]*

Neutrophils (%)~

43 (12.6)

46 (9.9)

66.5 (7.1)

43.5(5.6)

  1. ~ mean (SEM), # geometric mean (95% confidence interval), N/A not applicable
  2. *p < 0.05 vs. control, **p < 0.05 vs. control and/or EB