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Table 3 Univariate regression analysis (one variable at a time) for relationship between lung function and TLR4 wild-type and polymorphic groups

From: Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index

Lung Function

Model I

FEV1

Model II

FVC

Model III

FEV1/FVC

Model IV

FEF25_75

Variable

Parameter Estimate (SE)

Parameter Estimate (SE)

Parameter Estimate (SE)

Parameter Estimate (SE)

Age, yrs

-0.033 (0.001)***

-0.036 (0.001)***

-0.001 (0.000)***

-0.041 (0.002)***

BMI (reference is normal)

    

   Overweight

0.074 (0.055)

0.134 (0.067)*

-0.010 (0.004)*

0.057 (0.075)

   Obese

-0.060 (0.057)

-0.106 (0.069)

0.003 (0.004)

0.096 (0.077)

Smoking status (reference is never smoker)

    

   Ever smoker

-0.032 (0.044)

0.012 (0.054)

-0.011 (0.003)**

-0.151 (0.060)*

Sex (reference is female)

    

   Male

1.031 (0.037)***

1.336 (0.044)***

-0.011 (0.003)**

0.934 (0.056)***

TLR4299 (reference is wild-type)

    

   polymorphic groups

0.134 (0.064)*

0.185 (0.078)*

-0.002 (0.004)

0.091 (0.088)

Grain Dust (reference is not exposed)

    

   Exposed

0.299 (0.045)***

0.426 (0.054)***

-0.011 (0.003)**

0.214 (0.061)**

Household Smoking (Reference is No)

    

   Yes

0.021 (0.069)

0.001 (0.083)

0.004 (0.005)

0.037 (0.093)

  1. *** p < 0.001; ** p < 0.01; * p < 0.05
  2. Normal: <25; Overweight: 25-30; Obese: >30