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Table 4 Multiple regression analysis for relationship between lung function and TLR4 wild-type and polymorphic groups, adjusting for age, BMI, sex and smoking

From: Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index

Lung Function

FEV1

FVC

FEV1/FVC

FEF25_75

Variable

Parameter Estimate (SE)

Parameter Estimate (SE)

Parameter Estimate (SE)

Parameter Estimate (SE)

Age, yrs

-0.033 (0.001)***

-0.036 (0.001)***

-0.001 (0.000)***

-0.041 (0.002)***

BMI (reference is normal: <25)

    

   Overweight (BMI: 25-30)

0.019 (0.035)

0.026 (0.042)

-0.00002 (0.004)

0.065 (0.064)

   Obese (BMI: >30)

-0.057 (0.035)

-0.145 (0.043)**

0.015 (0.004)***

0.232(0.065)***

Smoking status (reference is never smoker)

    

   Ever smoker

-0.074 (0.027)**

-0.056 (0.033)

-0.007 (0.003)*

-0.176 (0.047)***

Sex (reference is female)

    

   Male

1.059 (0.028)***

1.367 (0.034)***

-0.010 (0.003)**

0.959(0.048)***

TLR4299 (reference is wild-type)

    

   polymorphic groups

-0.020 (0.039)

0.003 (0.048)

0.007 (0.009)

0.062 (0.135)

Interactions

    

BMI and TLR4299

(reference is < 25 BMI and Wild type)

    

   25-30 BMI group and polymorphic group

  

-0.008 (0.011)

0.040 (0.172)

   >30 BMI group and polymorphic group

  

-0.021 (0.011)#

-0.432 (0.175)*

  1. *** p < 0.001; ** p < 0.01; * p < 0.05 # p < 0.10