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Table 4 Multiple regression analysis for relationship between lung function and TLR4 wild-type and polymorphic groups, adjusting for age, BMI, sex and smoking

From: Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index

Lung Function FEV1 FVC FEV1/FVC FEF25_75
Variable Parameter Estimate (SE) Parameter Estimate (SE) Parameter Estimate (SE) Parameter Estimate (SE)
Age, yrs -0.033 (0.001)*** -0.036 (0.001)*** -0.001 (0.000)*** -0.041 (0.002)***
BMI (reference is normal: <25)     
   Overweight (BMI: 25-30) 0.019 (0.035) 0.026 (0.042) -0.00002 (0.004) 0.065 (0.064)
   Obese (BMI: >30) -0.057 (0.035) -0.145 (0.043)** 0.015 (0.004)*** 0.232(0.065)***
Smoking status (reference is never smoker)     
   Ever smoker -0.074 (0.027)** -0.056 (0.033) -0.007 (0.003)* -0.176 (0.047)***
Sex (reference is female)     
   Male 1.059 (0.028)*** 1.367 (0.034)*** -0.010 (0.003)** 0.959(0.048)***
TLR4299 (reference is wild-type)     
   polymorphic groups -0.020 (0.039) 0.003 (0.048) 0.007 (0.009) 0.062 (0.135)
Interactions     
BMI and TLR4299
(reference is < 25 BMI and Wild type)
    
   25-30 BMI group and polymorphic group    -0.008 (0.011) 0.040 (0.172)
   >30 BMI group and polymorphic group    -0.021 (0.011)# -0.432 (0.175)*
  1. *** p < 0.001; ** p < 0.01; * p < 0.05 # p < 0.10