| AP318 |  |  |  | CTRL |  |  |  |
---|---|---|---|---|---|---|---|---|
Parameter | Baseline | Sepsis /VILI | 3Â h | 6Â h | Baseline | Sepsis /VILI | 3Â h | 6Â h |
Ventilation | Â | Â | Â | Â | Â | Â | Â | Â |
V t (mL kg −1 ) | 8.8 ± 1.4 | 25.4 ± 2.0 | 8.7 ± 0.6 | 8.7 ± 0.7 | 8.6 ± 0.9 | 25.8 ± 0.6 | 8.5 ± 0.4 | 8.2 ± 0.6 |
P endinsp (cmH 2 O) | 14 ± 2 | 21 ± 3 | 21 ± 2 | 19 ± 4 | 14 ± 1 | 21 ± 2 | 21 ± 3 | 19 ± 3 |
RR (min −1 ) | 28 ± 8 | 9 ± 2 | 33 ± 7 | 31 ± 5 | 33 ± 6 | 9 ± 1 | 36 ± 6 | 33 ± 9 |
PEEP (cmH 2 O) | 6 ± 1 | 1 ± 0 | 5 ± 1 | 5 ± 1 | 6 ± 1 | 1 ± 0 | 5 ± 0 | 6 ± 2 |
FiO 2 | 0.4 | 1.0 | 0.4 | 0.4 | 0.4 | 1.0 | 0.4 | 0.4 |
I:E | 1:2 | 1:2 | 1:2 | 1:2 | 1:2 | 1:2 | 1:2 | 1:2 |
PaCO 2 (mmHg) | 43 ± 4 | 35 ± 3 | 44 ± 5 | 42 ± 5 | 45 ± 3 | 36 ± 5 | 43 ± 5 | 42 ± 7 |
pH | 7.41 ± 0.03 | 7.50 ± 0.08 | 7.33 ± 0.08 | 7.34 ± 0.08 | 7.41 ± 0.04 | 7.47 ± 0.07 | 7.34 ± 0.05 | 7.32 ± 0.08 |
Hemodynamics | Â | Â | Â | Â | Â | Â | Â | Â |
MAP (mmHg) | 93 ± 13 | 103 ± 11 | 66 ± 13 | 68 ± 8 | 99 ± 13 | 115 ± 12 | 69 ± 12 | 62 ± 12 |
CO (L min −1 ) | 4.6 ± 0.7 | 4.7 ± 0.7 | 3.2 ± 0.9 | 3.9 ± 1.2 | 4.5 ± 0.5 | 4.6 ± 0.7 | 3.2 ± 0.5 | 3.4 ± 0.7 |
CVP (mmHg) | 12 ± 3 | 11 ± 2 | 12 ± 3 | 13 ± 2 | 11 ± 3 | 11 ± 3 | 13 ± 3 | 13 ± 3 |
MPAP (mmHg) | 22 ± 3 | 23 ± 3 | 33 ± 5 | 30 ± 8 | 21 ± 5 | 26 ± 4 | 37 ± 8 | 33 ± 12 |
NA (μg kg−1 min−1) | 0 | 0 | 0.8 ± 1.3 | 2.7 ± 5.0 | 0 | 0 | 0.3 ± 0.5 | 3.1 ± 5.7 |