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Table 2 Ventilation and hemodynamic data

From: Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model

 

AP318

   

CTRL

   

Parameter

Baseline

Sepsis /VILI

3 h

6 h

Baseline

Sepsis /VILI

3 h

6 h

Ventilation

        

V t (mL kg −1 )

8.8 ± 1.4

25.4 ± 2.0

8.7 ± 0.6

8.7 ± 0.7

8.6 ± 0.9

25.8 ± 0.6

8.5 ± 0.4

8.2 ± 0.6

P endinsp (cmH 2 O)

14 ± 2

21 ± 3

21 ± 2

19 ± 4

14 ± 1

21 ± 2

21 ± 3

19 ± 3

RR (min −1 )

28 ± 8

9 ± 2

33 ± 7

31 ± 5

33 ± 6

9 ± 1

36 ± 6

33 ± 9

PEEP (cmH 2 O)

6 ± 1

1 ± 0

5 ± 1

5 ± 1

6 ± 1

1 ± 0

5 ± 0

6 ± 2

FiO 2

0.4

1.0

0.4

0.4

0.4

1.0

0.4

0.4

I:E

1:2

1:2

1:2

1:2

1:2

1:2

1:2

1:2

PaCO 2 (mmHg)

43 ± 4

35 ± 3

44 ± 5

42 ± 5

45 ± 3

36 ± 5

43 ± 5

42 ± 7

pH

7.41 ± 0.03

7.50 ± 0.08

7.33 ± 0.08

7.34 ± 0.08

7.41 ± 0.04

7.47 ± 0.07

7.34 ± 0.05

7.32 ± 0.08

Hemodynamics

        

MAP (mmHg)

93 ± 13

103 ± 11

66 ± 13

68 ± 8

99 ± 13

115 ± 12

69 ± 12

62 ± 12

CO (L min −1 )

4.6 ± 0.7

4.7 ± 0.7

3.2 ± 0.9

3.9 ± 1.2

4.5 ± 0.5

4.6 ± 0.7

3.2 ± 0.5

3.4 ± 0.7

CVP (mmHg)

12 ± 3

11 ± 2

12 ± 3

13 ± 2

11 ± 3

11 ± 3

13 ± 3

13 ± 3

MPAP (mmHg)

22 ± 3

23 ± 3

33 ± 5

30 ± 8

21 ± 5

26 ± 4

37 ± 8

33 ± 12

NA (μg kg−1 min−1)

0

0

0.8 ± 1.3

2.7 ± 5.0

0

0

0.3 ± 0.5

3.1 ± 5.7

  1. Data are presented as mean ± SD, no relevant intergroup differences. Vt: tidal volume; Pendinsp: end-inspiratory pressure; PEEP: positive end-expiratory pressure; RR: respiratory rate; FiO2: fraction of inspired oxygen; I:E: inspiration to expiration quotient; PaCO2: arterial partial pressure of carbon dioxide; MAP: mean arterial pressure; CO: cardiac output; CVP: central venous pressure; MPAP: mean pulmonary arterial pressure; NA: noradrenaline dosage.