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Table 3 Distribution of histopathological lung injury summarized in figure 3

From: Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model

 

non-dependent

dependent

Parameter

AP318

CTRL

AP318

CTRL

Alveolar edema

0 ± 0

0.2 ± 0.6

0 ± 0

0.1 ± 0.2

Interstitial edema

1.0 ± 0.7

1.2 ± 1.1

1.0 ± 0.5

0.9 ± 0.7

Hemorrhage

0.3 ± 0.6

1.3 ± 1.2*

0.5 ± 0.8

1.2 ± 1.1*

Inflammatory infiltration

3.7 ± 0.9

3.5 ± 0.8

3.6 ± 1.0

3.7 ± 0.8

Epithelial destruction

0 ± 0

0.4 ± 0.9

0.1 ± 0.3

0.1 ± 0.2

Microatelectasis

3.6 ± 1.1

3.9 ± 1.2

3.3 ± 1.4

3.4 ± 1.3

Overdistension

3.9 ± 0.8

3.6 ± 1.1

3.5 ± 1.0

3.5 ± 0.9

  1. Data of lung regions (each containing periphery and bronchial area) are expressed as mean ± SD.
  2. *Indicates P < 0.05 vs. AP318 group.