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Table 1 Differences between unicentric and multicentric intrathoracic CD cases

From: Clinical spectrum of intrathoracic Castleman disease: a retrospective analysis of 48 cases in a single Chinese hospital

 

UCD

MCD

P

Age (mean, years)

30.44 ± 8.00

41.56 ± 13.50

0.004

Gender

   

 Male

8/50%

11/34.4%

0.2967

 Female

8/50%

21/65.6%

Pathological type

   

 Hyaline vascular

3/18.75%

16/50%

 

 Plasma cell

12/75%

12/37.5%

0.049

 Mixed

1/6.25%

4/12.5%

 

Non-symptomatic

8/50%

1/3.1%

<0.001

Fever

0

16/50%

<0.001

Pleural effusion

2/12.5%

13/40.6%

0.0475

Hepatomegaly and/or splenomegaly

0

16/50%

<0.001

Anemia

3/18.8%

15/46.9%

0.0578

Hemoglobin (g/l)

133.13 ± 29.70

108.66 ± 26.60

0.0059

Platelet (×10 9 /l)

   

 >300 × 109/l

4/25%

12/37.5%

0.6785

 <100 × 109/l

1/8.3%

2/10%

 

Hypoalbuminia

4/25%

22/68.8%

0.0041

Elevation of serum LDH ‡

5/30%

5/16.1%

0.6731

HIV-Ab

   

 Not done

0

6/18.75%

 

 Negative

16/100%

26/100% (n = 26)

1

Chemotherapy cases

0

28/87.5%

<0.001

Outcomes

   

 Cured

16/100%

0

 

 Improved

0

18/56.3%

 

 Stable

0

7/21.9%

<0.001

 Died

0

3/9.4%

 

 Lost follow-up

0

4/12.5%

 
  1. ‡Fifteen UCD cases and 31 MCD cases were detected with serum LDH. LDH: lactate dehydrogenase, HIV: human immunodeficiency virus.