Safety and performance analysis of acriflavine and methylene blue for in vivo imaging of precancerous lesions using fibered confocal fluorescence microscopy (FCFM): an experimental study

Table 1 Histological lesions obtained and imaged with CellVizio ® according to carcinogen exposure duration (number of weeks after first implant implementation)

	>3 weeks	>6 weeks	>9 weeks	>12 weeks	>15 weeks	>18 weeks
Reserve cell hyperplasia	1	2	3	5	7	6
Mild dysplasia	0	2	0	1	1	2
Moderate dysplasia	0	0	2	0	2	2
Severe dysplasia	0	0	1	0	0	4
Carcinoma	0	0	2	0	4	5

This table shows that the number of lesion increases over time exposure (1 lesion at 3 weeks and 19 lesions after 18 weeks), and that the number of severe lesions also increases over time exposure (none at 3 weeks and 4 severe dysplasia and 5 carcinomas after 18 weeks).

ISSN: 1471-2466