Prevalence and impact of Streptococcus pneumoniae in adult cystic fibrosis patients: a retrospective chart review and capsular serotyping study

Table 1 Adult cystic fibrosis patient demographics from those with isolated Pneumococcus cultures

Patient	Age^a	Sex	Mutation 1	Mutation 2	BMI^b	FVC (L)^c(% predicted)	FEV¹(L)^d(% predicted)	Pancreatic sufficient	Smoker status	CF Co-morbidities	Chronic pathogens^e
1	30	M	M1101K	M1101K	21.87	1.62 (35)	0.76 (20)	N	N	N	PA, SA, HI, Bcc
2	23	M	F508del	M1101K	16.05	3.29 (61)	0.94 (20)	N	N	Liver disease	PA, SA
3	30	F	F508del	P67L	32.03	N/A	N/A	Y	Y	N	SA
4	28	M	F508del	F508del	18.23	3.75 (68)	2.42 (54)	N	N	Sinus	PA, Bcc
5	29	F	F508del	F508del	15.58	2.06 (53)	1.08 (32)	N	N	CFRD, Sinus	PA
6	24	M	F508del	D110H	24.38	7.57 (140)	5.98 (128)	Y	Y	N	HI
7	24	M	F508del	F508del	16.20	3.77 (73)	1.4 (32)	Y	N	Sinus	PA
8	30	M	3659delC	394delTT	18.79	3.95 (75)	1.80 (41)	N	Y	Liver disease	PA
9	28	M	F508del	F508del	21.20	6.1 (117)	4.3 (100)	N	N	N	PA, SA
10	23	M	F508del	G551D	20.1	5.08 (88)	3.55 (74)	N	N	Sinus	PA, SA
11	30	F	F508del	Unknown	19.0	1.58 (35)	1.08 (29)	N	N	CFRD	PA
12	18	M	F508del	G178R	20.8	4.04 (107)	3.01 (86)	N	Y	Arthropathy, Sinus	SA, HI
13	28	F	F508del	F508del	19.7	2.48 (73)	1.5 (51)	N	N	N	PA
14	40	F	F508del	F508del	25.4	4.45 (134)	3.08 (110)	N	Y	CFRD, Arthropathy	PA, HI
15	22	M	F508del	F508del	21.7	4.26 (85)	2.94 (68)	N	N	Arthropathy	PA, SA

^aAge at time of first isolation of S. pneumoniae.
^bBMI: body mass index.
^cFVC: forced volume capacity, defined as an average of two values in the year preceding time of pneumococcus isolation.
^dFEV₁: forced expiratory volume, defined as an average of two values in the year preceding time of pneumococcus isolation.
^ePA: P. aeruginosa, SA: S. aureus, HI: Haemophilus influenzae, Bcc: Burkholderia cepacia complex; chronicity as defined by repeated isolation of pathogen on at least 50% of cultures over the prior two years.

ISSN: 1471-2466