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Table 3 Comparison of subject groups: IPF vs non-IPF

From: Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias

 

IPF (n = 36)

Non-IPF (n = 38)

P

Pulmonary function tests

   

 %FVC, %

71.5 ± 20.7

72.9 ± 19.5

NS

 %DLCO, %

56.0 ± 23.9

52.5 ± 19.9

NS

Quantitative CT indices

   

 HAA% (>-200 HU), %

1.90 ± 1.31

1.76 ± 0.99

NS

 LAA% (<-960 HU), %

5.25 ± 5.17

2.64 ± 2.62

<0.01

 CA%, %

1.50 ± 2.41

0.41 ± 0.80

<0.01

 MLD, HU

−767.4 ± 51.0

−749.1 ± 54.6

NS

 SD-LD, HU

197.6 ± 24.6

194.3 ± 20.7

NS

 Kurtosis

2.54 ± 1.87

2.21 ± 1.82

NS

 Skewness

1.67 ± 0.44

1.56 ± 0.45

NS

CT visual scores

   

 GGO score [0-5]

0.21 ± 0.25

0.67 ± 0.61

<0.01

 Fibrosis score [0-5]

2.10 ± 0.44

1.23 ± 0.59

<0.01

 Fibrosis score ≥2 in any field

35 (97 %)

13 (34 %)

<0.01

  1. Values expressed as mean ± standard deviation or number (%)
  2. Numbers in square brackets represent theoretical score range
  3. IPF idiopathic pulmonary fibrosis, NSIP nonspecific interstitial pneumonia, %FVC percentage of predicted forced vital capacity, %DLCO percentage of predicted diffusion capacity of carbon monoxide, CT computed tomography, HAA% percentage of lung field occupied by high-attenuation areas, LAA% percentage of lung field occupied by low-attenuation areas, CA% percentage of lung field occupied by cystic areas, MLD mean lung density, HU hounsfield units, SD-LD standard deviation of lung densities, GGO ground-glass opacity