Fig. 1

Challenge and sampling regime. Schematic diagram depicting the bleomycin and saline treatments administered to individual lung segments (a) two spatially distinct lung segments, which received the different treatments. The left caudal (LC) segment in sheep 1–4 received 3U bleomycin per segment, and the right medial (RC) segment received sterile saline as a control. The treatment and control segments were reversed in sheep 5–9 (b) Diagram indicating the time line for treatment administration, lung function and sample collection