Fig. 7

Alveolar airspace is significantly reduced in response to bleomycin (b). Changes to alveolar tissue percentage, showing increased tissue volume (a) and airspace percentage, showing decreased airspace volume (b), were assessed in H&E stained lung segments taken at autopsy. Measurements were taken from three differentially treated segments in each sheep using point-counting methods. Fifteen fields were assessed in each segment to obtain an average value. Values are shown as mean ±SEM for each segment for all animals, n=9. Significance was determined using a matched- ANOVA ****, p<0.0001