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Table 1 Absolute values of the morphometric analysis for inflammatory markers in the airway and lung tissue

From: Y-27632 is associated with corticosteroid-potentiated control of pulmonary remodeling and inflammation in guinea pigs with chronic allergic inflammation

AIRWAY

     

BIOMARKERS

SAL (n = 8)

OVA (n = 8)

OVA-RHO (n = 8)

OVA-C (n = 8)

ORC (n = 8)

Eosinophils

4.15 ± 1.26

33.56 ± 4.66 ***

12.17 ± 1.57 */ #

16.83 ± 4.34 *

11.46 ± 3.74 *

IFN-γ

9.37 ± 0.97

35.36 ± 2.50 ***

17.98 ± 1.14 +

18.02 ± 0.83 +

12.48 ± 1.44 + / **

IL-2

2.39 ± 0.57

32.76 ± 6.95 ***

13.31 ± 0.62 +

12.47 ± 0.97 +

10.09 ± 1.29 +

IL-4

4.69 ± 0.68

13.69 ± 1.26 ***

6.34 ± 1.58 +

8.13 ± 1.24 +

5.61 ± 0.85 +

IL-5

4.53 ± 0.75

21.76 ± 1.23 ***

11.43 ± 1.74 *

11.65 ± 2.12 *

9.67 ± 1.34 *

IL-13

1.19 ± 0.75

13.42 ± 0.45 ***

4.37 ± 1.12 *

6.64 ± 1.58 *

4.59 ± 0.68 *

LUNG TISSUE

     

BIOMARKERS

SAL (n = 8)

OVA (n = 8)

OVA-RHO (n = 8)

OVA-C (n = 8)

ORC (n = 8)

Eosinophils

0.75 ± 0.27

11.48 ± 0.75 ***

4.13 ± 0.15 */ #

6.15 ± 2.19 *

2.73 ± 1.22 */ #

IFN-γ

11.26 ± 1.47

25.48 ± 1.13 ***

16.27 ± 0.76 +

19.08 ± 0.61 +

13.81 ± 0.78 + / **

IL-2

2.79 ± 0.49

19.53 ± 1.39 ***

7.48 ± 0.62 +

9.26 ± 0.45 +

4.13 ± 0.60 + / **

IL-4

2.57 ± 0.37

18.78 ± 1.53 ***

11.26 ± 0.92 +

8.32 ± 0.40 +

6.89 ± 0.96 +

IL-5

2.25 ± 0.54

13.52 ± 0.66 ***

5.76 ± 0.47 *

7.04 ± 0.93 *

5.90 ± 1.00 *

IL-13

1.38 ± 0.59

11.37 ± 2.26 ***

4.74 ± 1.32 *

3.61 ± 1.07 *

2.62 ± 0.76 *

  1. The eosinophils, IFN-γ, IL-2, IL-4, IL-5, IL-13, are expressed in positive cells/104 μm2. ***P < 0.001, compared with the SAL group; *P < 0.05, compared with the OVA group; #P < 0.05, compared with the OVA-C group, +P < 0.001, compared with the OVA group, **P < 0.05, compared with the OVA-RHO and OVA-C groups