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Table 3 Absolute values of the morphometric analysis for oxidative stress and transcription factor markers in the airway and lung tissue

From: Y-27632 is associated with corticosteroid-potentiated control of pulmonary remodeling and inflammation in guinea pigs with chronic allergic inflammation

AIRWAY

     

BIOMARKERS

SAL (n = 8)

OVA (n = 8)

OVA-RHO (n = 8)

OVA-C (n = 8)

ORC (n = 8)

iNOS

5.46 ± 0.17

17.44 ± 1.47 ***

7.47 ± 0.85 *

10.20 ± 2.12 *

9.70 ± 0.81 *

8-iso-PGF2α

11.25 ± 0.38

26.47 ± 1.28 ***

14.48 ± 2.97 *

15.26 ± 1.37 *

13.28 ± 1.16 *

NF-κB

6.18 ± 0.48

17.36 ± 1.46 ***

7.69 ± 0.42 *

7.29 ± 1.34 *

5.35 ± 0.89 *

LUNG TISSUE

     

BIOMARKERS

SAL (n = 8)

OVA (n = 8)

OVA-RHO (n = 8)

OVA-C (n = 8)

ORC (n = 8)

iNOS

1.26 ± 0.37

10.14 ± 0.38 ***

4.37 ± 0.85 *

5.42 ± 0.94 *

4.67 ± 0.37 *

8-iso-PGF2α

1.15 ± 0.38

18.84 ± 1.85 ***

9.48 ± 0.85 *

10.14 ± 0.73 *

2.18 ± 0.54 * / **

NF-κB

1.38 ± 0.31

18.37 ± 1.78 ***

11.37 ± 1.63 *

10.88 ± 0.96 *

5.70 ± 0.94 * / **

  1. The iNOS and NF-κB are expressed in positive cells/104 μm2. The 8-iso-PGF2α is expressed in percentage of increase (%). ***P < 0.001, compared with the SAL group; *P < 0.05, compared with the OVA group; **P < 0.05, compared with the OVA-RHO and OVA-C groups