Table 4 Stratification analyses between the genotypes of rs3748067 and CWP risk
From: Polymorphisms in interleukin 17A gene and coal workers’ pneumoconiosis risk in a Chinese population
Variables | Cases/controls | Genotypes (cases/controls) | P a | OR (95 % CI)a | |||
|---|---|---|---|---|---|---|---|
GG/GA | AA | ||||||
n | % | n | % | ||||
Total | 693/690 | 679/659 | 98.0/95.5 | 14/31 | 2.0/4.5 | 0.014 | 0.44 (0.23-0.85) |
Age | |||||||
<68 | 276/405 | 270/388 | 97.8/95.8 | 6/17 | 2.2/4.2 | 0.040 | 0.33 (0.11-0.95) |
≥68 | 417/285 | 409/271 | 96.9/95.1 | 8/14 | 1.9/4.9 | 0.041 | 0.68 (0.16-0.96) |
Exposure years | |||||||
<27 | 270/267 | 264/255 | 97.8/95.5 | 6/12 | 2.2/4.5 | 0.210 | 0.52 (0.19-1.44) |
≥27 | 423/423 | 415/404 | 95.5/98.1 | 8/19 | 1.9/4.5 | 0.041 | 0.42 (0.18-0.97) |
Smoking status | |||||||
never | 340/359 | 333/345 | 98.0/96.1 | 7/14 | 2.1/3.9 | 0.228 | 0.56 (0.22-1.43) |
ever | 353/331 | 346/214 | am | 7/17 | 2.0/5.1 | 0.022 | 0.34 (0.13-0.86) |
Stage | |||||||
I | 415/690 | 406/659 | 97.8/95.5 | 9/31 | 2.2/4.5 | 0.045 | 0.45 (0.21-0.98) |
II | 217/690 | 212/659 | 97.7/95.5 | 5/31 | 2.3/4.5 | 0.199 | 0.52 (0.19-1.41) |
III | 61/690 | 61/659 | 100/95.5 | 0/31 | 0/4.5 | ||