Table 5 Stratification analyses between the genotypes of rs8193036 and CWP risk
From: Polymorphisms in interleukin 17A gene and coal workers’ pneumoconiosis risk in a Chinese population
Variables | Cases/controls | Genotypes (cases/controls) | P a | OR (95 % CI)a | |||
|---|---|---|---|---|---|---|---|
CC/TC | TT | ||||||
Number | Percent | Number | Percent | ||||
Total | 693/690 | 639/609 | 92.2/88.3 | 54/81 | 7.8/11.7 | 0.011 | 0.63 (0.43-0.90) |
Age | |||||||
<68 | 276/405 | 258/354 | 93.5/87.4 | 18/51 | 6.5/12.6 | 0.025 | 0.50 (0.27-0.92) |
≥68 | 417/285 | 381/255 | 91.4/89.5 | 36/30 | 8.63/10.5 | 0.335 | 0.78 (0.47-1.30) |
Exposure years | |||||||
<27 | 270/267 | 253/233 | 93.7/82.3 | 17/34 | 6.3/12.7 | 0.014 | 0.46 (0.25-0.85) |
≥27 | 423/423 | 386/376 | 91.3/88.9 | 37/47 | 8.8/11.1 | 0.227 | 0.75 (0.48-1.19) |
Smoking status | |||||||
never | 340/359 | 309/319 | 90.9/88.9 | 31/40 | 9.1/11.1 | 0.448 | 0.82 (0.50-1.36) |
ever | 353/331 | 330/290 | 93.5/87.6 | 23/41 | 6.5/12.4 | 0.002 | 0.41 (0.23-0.71) |
Stage | |||||||
I | 415/690 | 391/609 | 94.2/88.3 | 24/81 | 5.8/11.7 | 0.001 | 0.46 (0.28-0.74) |
II | 217/690 | 196/609 | 90.3/88.3 | 21/81 | 9.7/11.7 | 0.437 | 0.81 (0.48-1.37) |
III | 61/690 | 52/609 | 85.3/88.3 | 9/81 | 14.8/11.7 | 0.445 | 1.36 (0.62-2.96) |