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Table 2 Long-term exacerbation rate. Long-term (months 3–12) exacerbation rate in all patients, based on cut-points of ≥2, ≥6, and ≥10 reliever inhalations/day in the week preceding the 2-month visit

From: Reliever salbutamol use as a measure of exacerbation risk in chronic obstructive pulmonary disease

Mean reliever use (inhalations/day)

Exacerbation ratea or ratio

95 % CI

P-value

<2

0.596

(0.470, 0.756)

 

2–5

0.724

(0.594, 0.882)

 

6–9

0.996

(0.806, 1.230)

 

≥10

1.403

(1.115, 1.766)

 

2–5 versus <2

1.214

(0.891, 1.654)

0.22

6–9 versus <2

1.670

(1.215, 2.296)

0.0016

≥10 versus <2

2.353

(1.687, 3.282)

<0.001

  1. CI confidence interval
  2. aRates are normalized for 10 months and expressed as events per year. Analysis adjusted for treatment effects