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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study

Fig. 1

eGWAS of combined 8 ARDS models. The plot depicts chi-square P values (−log10) on the y axis arranged by chromosomal location (x axis). P values for each gene were calculated for 97 sham-operated or vehicle exposed control microarray samples and 122 ARDS microarray samples as the likelihood of finding repeated differential expression compared with expected using χ2 analysis. Out of 32160 tested gene entries, 42 genes demonstrated a significant differential expression. The dashed line indicates the Bonferroni threshold (P = 1.55 × 10−6). The gene symbols indicate known ARDS genes that are most significantly associated with ARDS throughout all tested models, where underscored symbols indicate new candidate genes

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