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Table 3 The relationships between changes in peak oxygen uptake and peak minute ventilation and explanatory variables

From: Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study

Variable

Unadjusted

Adjusted

p-value

B

p-value

B

St.B*

95 % CI

ΔV̇O2peak (L ∙ min−1)

Age (years)

−0.006

0.273

−0.011

−0.238

−0.020–−0.002

0.023

Sex

−0.146

0.042

0.022

0.039

−0.110–0.155

0.737

Height (m)

−0.652

0.145

    

V̇O2peak at baseline (L ∙ min−1)

−0.178

0.004

−0.260

−0.515

−0.379–−0.141

<0.001

Smoking during follow-up

−0.108

0.144

−0.139

−0.240

−0.257–−0.021

0.021

ΔFEV1 (L)

0.440

<0.001

0.254

0.251

0.024–0.484

0.031

ΔFVC (L)

0.271

<0.001

    

Δ Weight (kg)

−0.004

0.604

    

ΔICrest (L)

0.317

<0.001

0.294

0.492

0.110–0.478

0.002

ΔICdynamic (L)

0.202

0.037

−0.105

−0.140

−0.315–0.105

0.320

Strenuous physical activity

0.020

0.593

    

Light physical activity

0.079

0.131

    

Exacerbations

−0.100

0.166

    

Time between CPET1 and CPET2

0.005

0.907

    
      

R2 = 0.567

ΔV̇Epeak (L ∙ min−1)

      

Age (years)

−0.075

0.756

−0.131

−0.070

−0.545–0.283

0.528

Sex

−2.484

0.404

3.180

0.163

−2.111–9.732

0.203

Height (m)

−3.447

0.848

    

Epeak at baseline (L ∙ min−1)

−0.163

0.032

−0.259

−0.422

−0.415–−0.103

0.002

Smoking during follow-up

−3.506

0.249

    

ΔFEV1 (L)

19.220

<0.001

11.845

0.285

1.699–21.990

0.023

ΔFVC (L)

11.626

<0.001

    

Δ Weight (kg)

−0.324

0.254

    

ΔICrest (L)

13.030

<0.001

12.135

0.497

3.759–20.510

0.005

ΔICdynamic (L)

11.109

0.004

−4.219

−0.137

−13.748–5.310

0.379

Strenuous physical activity

0.984

0.512

    

Light physical activity

2.241

0.297

    

Exacerbations

−4.775

0.104

    

Time between CPET1 and CPET2

−0.299

0.870

    
      

R2 = 0.447

  1. 95 % confidence interval (CI) examined by linear regression in bivariate and multivariate analyses
  2. CPET: cardiopulmonary exercise test; V̇O2peak: peak oxygen uptake per minute; ΔV̇O2peak: V̇O2peak at CPET2 minus V̇O2peak at CPET1; FEV1: forced expiratory volume in one second; ΔFEV1: FEV1 at CPET2 minus FEV1 at CPET1; FVC: forced vital capacity; ΔFVC and Δweight were calculated like ΔFEV1. IC: inspiratory capacity. ΔICrest was calculated as IC at rest at CPET2 minus IC at rest at CPET1. ΔIC was calculated as IC at rest minus IC at the end of the test for both CPET1 and CPET2. ΔICdynamic was calculated as ΔIC at CPET2 minus ΔIC at CPET1; V̇E: minute ventilation per minute; ΔV̇Epeak: peak V̇E at CPET2 minus peak V̇E at CPET1; R2: The coefficient of determination
  3. *St.B: Standardised beta