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Table 2 Data from immunohistochemistry staining of bronchial biopsies for markers of proliferation and apoptosis

From: Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium – an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects

Study group

 

Healthy controls

Allergic rhinitics

Asthmatics β2

Asthmatics ICS

Exposure

 

AIR

DE

AIR

DE

AIR

DE

AIR

DE

Pro-apoptotic markers

Bad

10.8 (5.5 - 20.1)

11.8 (9.1 - 23.3)

29.8 (9.6 - 34.2)

14.7 (4.0 - 27.4)

12.4 (6.0 - 20.7)

21.5 (4.3 - 41.4)

14.4 (6.2 - 22.8)

19.0 (10.7 - 28.8)

Bak

15.4 (3.8 - 36.4)

17.2 (9.1 - 28.0)

18.9 (8.8 - 31.7)

26.4 (8.3 - 31.9)

14.5 (10.3 - 33.7)

27.0 (13.1 - 38.5)

21.7 (13.3 - 33.2)

23.8 (8.6 - 28.7)

Anti-apoptotic marker

Bcl-2

4.5 (0–11.4)

0.06* (0.01 - 0.6)

0.36 (0.19 - 1.2)

0.07 (0–44.2)

0.34 (0.02 - 5.1)

2.8 (0–17.1)

0.49 (0–3.3)

0.08 (0–5.1)

Death receptor

Fas

2.8 (1.4 - 4.6)

1.4 (0.4 - 5.5)

1.8 (1.0 - 5.9)

1.7 (0.3 - 10.8)

1.9 (0.7 - 3.3)

1.8 (0.4 - 3.0)

1.3 (0.5 - 2.7)

2.0 (0.5 - 1.2)

Caspase cleavage product

P85 PARP

1.7 (0.6 - 6.8)

1.7 (1.0 - 2.8)

3.8 (0.6 - 9.2)

2.6 (0.8 - 6.0)

2.2 (0.4 - 6.9)

4.3 (1.1 - 7.2)

2.1 (0.3- 4.6)

2.6 (0.1 - 4.1)

Proliferation marker

Ki67

1.9 (0.1 - 5.0)

0.7 (0.3 - 3.6)

1.7 (0.4 - 14.6)

11.2 (1.5 - 34.1)

3.1 (0.6 - 10.2)

1.3 (0.2 - 3.4)

1.2 (0.2 - 11.9)

1.7 (0.9 - 8.0)

  1. Data is given as the % positive staining within the epithelium calculated (median percentages and inter quartile ranges)
  2. Within group significant difference between AIR and diesel exhaust (DE) exposure, Wilcoxon Signed Ranks test. * p = 0.02