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Table 2 Comparison of methods for the detection of interstitial lung abnormalities in COPDGene and Framingham Heart Study (FHS) participants

From: A comparison of visual and quantitative methods to identify interstitial lung abnormalities

COPDGene HAAs < 10 %a HAAs ≥ 10 %a HAAs < 95th percentile (HAA < 6.44 %)a HAAs ≥ 95 percentile (HAA ≥ 6.44 %)a
No ILAa 1909 21 1850 80
ILA 158 5 139 24
  Kappa 0.03, p = 0.03 Kappa 0.13, p < 0.0001
Framingham Heart Study HAAs < 10 % HAAs ≥ 10 % HAAs < 95th percentile HAAs ≥ 95 percentile
No ILAa 1987 306 2188 105
ILA 104 46 132 18
  Kappa 0.11, p = <0.0001 Kappa 0.08, p < 0.0001
COPDgene Cohort:
HAAs at 10 % Sensitivity 3 % Specificity 99 % PPV 19 % NPV 92 %
HAAs at 95th% Sensitivity 15 % Specificity 96 % PPV 23 % NPV 93 %
Framingham Cohort:
HAAs at 10 % Sensitivity 31 % Specificity 87 % PPV 13 % NPV 95 %
HAAs at 95th% Sensitivity 12 % Specificity 95 % PPV 15 % NPV 94 %
  1. aHAAs high attenuation areas (defined by the percentage of the lung occupied by high attenuation areas between −600 and −250 Hounsfield Units) [11]
  2. bNumber of subjects grouped as “no ILA” that are classified as indeterminate: COPDgene: HAA <10 % - n = 739, HAAs ≥ 10 % - n = 18, HAAs < 95 % – n = 698, HAAs ≥ 95 % – n = 59
  3. cNumber of subjects grouped as “no ILA” that are classified as indeterminate: Framingham: HAA <10 % - n = 805, HAAs ≥ 10 % - n = 184, HAAs < 95 % – n = 926, HAAs ≥ 95 % – n = 63