Total | TYMS high expression | TYMS low expression | |||||
---|---|---|---|---|---|---|---|
n | n | % | n | % | P-value | ||
Age (mean (range)) | 57 (32–79) | 54 (32–79) | 66 (60–78) | 1 | |||
Gender | Male | 40 | 26 | 65.0 | 14 | 35.0 | 0.419 |
Female | 22 | 12 | 54.5 | 10 | 45.5 | ||
Smoking habit | Current smoker | 24 | 18 | 75.0 | 6 | 25.0 | 0.056 |
Former smoker | 22 | 14 | 63.6 | 8 | 36.4 | ||
Never smoker | 16 | 6 | 37.5 | 10 | 62.5 | ||
Histology | Adenocarcinoma | 49 | 27 | 55.1 | 22 | 44.9 | 0.071 |
NSCLC nos | 7 | 7 | 100 | 0 | 0 | ||
Squamous cell carcinoma | 6 | 4 | 66.7 | 2 | 33.3 | ||
ECOG performance status | ECOG0 | 27 | 19 | 70.4 | 8 | 29.6 | 0.392 |
ECOG1 | 32 | 17 | 53.1 | 15 | 46.9 | ||
ECOG2 | 3 | 2 | 66.7 | 1 | 33.3 | ||
Line of treatment | 1st line | 16 | 9 | 56.3 | 7 | 43.8 | 0.661 |
2nd line | 14 | 10 | 71.4 | 4 | 28.6 | ||
3rd, further lines | 32 | 19 | 59.4 | 13 | 40.6 | ||
Response | No | 45 | 30 | 66.7 | 15 | 33.3 | 0.025 |
Yes | 7 | 1 | 14.3 | 6 | 85.7 | ||
Not evaluatable | 10 | 7 | 70.0 | 3 | 30.0 | ||
Progression | No | 24 | 4 | 16.7 | 20 | 83.3 | 0.003 |
Yes | 38 | 34 | 89.5 | 4 | 10.5 |