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Table 3 Diagnostic performance of (A) YKL-40 serum levels (ng/ml) for the differential diagnosis of Tuberculosis, (B) MIP-1a Serum levels (ng/ml) and (C) MIP-1a Pleural levels (ng/ml) for the differential diagnosis of Lung Cancer, at the optimal cut-off points of the ROC analysis

From: Expression of YKL-40 and MIP-1a proteins in exudates and transudates: biomarkers for differential diagnosis of pleural effusions? A pilot study

  Optimal cut off point Sensitivity (%) Specificity (%) +LR -LR PPV (%) NPV (%) AUC 95 % CIs
A. YKL-40 Serum levels (ng/ml)
TB vs LCa 122.8 90.9 100.0 >20.0 0.09 100.0 85.7 0.857 0.598–1.000
TB vs MCa 118.9 90.9 100.0 >20.0 0.09 100.0 87.5 0.913 0.745–1.000
TB vs PN 113.2 90.9 100.0 >20.0 0.09 100.0 87.5 0.975 0.913–1.000
B. MIP-1a Serum levels (ng/ml)
LCa vs ΤΒ 22.5 100.0 70.0 3.3 >20.0 100.0 30.0 0.850 0.667–1.000
LCa vs MCa 19.8 66.7 100.0 >20.0 0.33 100.0 60.0 0.731 0.488–0.975
LCa vs PN 19.4 80.0 100.0 >20.0 0.20 100.0 75.0 0.875 0.694–1.000
C. MIP-1a Pleural levels (ng/ml)
LCa vs TB 17.0 100.0 60.0 2.5 >20.0 100.0 60.0 0.857 0.676–1.000
LCa vs MCa 3.8 57.1 80.0 2.9 1.9 57.1 80.0 0.679 0.418–0.939
LCa vs PN 8.2 71.4 87.5 5.7 3.1 71.4 87.5 0.839 0.630–1.000
  1. +LR positive likelihood ratio, -LR negative likelihood ratio, PPV positive predictive values, NPV Negative predictive value, AUC Area Under the Curve, 95 % CI 95 % Confidence Intervals