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Table 2 Summary of the results of laboratory testing, bronchoalveolar lavage, and pulmonary function test

From: Interstitial lung disease in clinically amyopathic dermatomyositis with and without anti-MDA-5 antibody: to lump or split?

  MDA-5 positive MDA-5 negative p value
(n = 10) (n = 6)
PaO2/FiO2 ratio 296 (274–359) 343 (332–357) 0.689
Laboratory data
 White blood cell count (/μL) 5600 (4825–6300) 8150 (5775–10150) 0.573
 Aspartate aminotransferase (IU/L) 55.5 (40.5–92.3) 28.5 (23.5–33.5) 0.0225
 Alanine aminotransferase (IU/L) 27.0 (17.0–105) 17.0 (16.3–19.3) 0.252
 γ-glutamyl transpeptidase (IU/L) 40.5 (23.0–60.5) 15.5 (14.0–22.3) 0.00225
 Creatine phosphokinase (IU/L) 184 (90.3–467) 108 (85.8–268) 0.635
 Aldolase (U/L) 6.15 (3.58–8.45) 7.50 (4.45–8.45) 0.713
 C-reactive protein (mg/dL) 1.28 (0.90–2.94) 0.62 (0.36–3.53) 0.428
 Lactate dehydrogenase (IU/L) 368 (302–390) 297 (259–331) 0.0925
 Krebs von den Lungen-6 (U/mL) 600 (471–1072) 1700 (1027–3511) 0.0160
 Surfactant protein D (ng/dL) 32.5 (22.8–47.6) 181 (98.1–378) 0.00402
 Anti-ARS antibody 0 3 (50 %)  
  Anti Jo-1 0 1 (17 %)  
  Anti PL-12 0 1 (17 %)  
  Anti 0 J 0 1 (17 %)  
 Anti-PM/Scl-100 antibody 0 1 (17 %)  
Bronchoalveolar lavage
 Total cell count 300 (250–400) 500 (450–700) 0.131
 Neutrophil (%) 3.00 (2.50–6.50) 11.0 (8.50–51.5) 0.0855
 Eosinophil (%) 1.00 (0.00–1.00) 4.00 (2.00–5.50) 0.284
 Lymphocyte (%) 30.0 (24.5–37.0) 41.0 (22.0–42.0) 0.819
 Macrophage (%) 60.0 (59.5–70.5) 41.0 (23.0–44.0) 0.0396
 CD4+/CD8+ ratio 1.68 (1.13–3.62) 0.420 (0.340–0.490) 0.0167
Lung function test
 % Forced vital capacity 79.8 (67.4–90.4) 72.9 (53.4–93.6) 1.00
 % Diffusing capacity for carbon monoxide 56.6 (50.2–63.7) 56.9 (54.7–63.0) 0.730
  1. Categorical data are presented as numbers (percentages) and were analyzed using Fisher’s exact test. Continuous data are presented as medians (interquartile ranges) and were analyzed using the Mann–Whitney U test. A p value of <0.05 was considered statistically significant
  2. Abbreviation: MDA-5, anti-melanoma differentiation-associated gene 5