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Table 4 Comparisons of characteristics and examination findings between anti-MDA-5-positive survivors and non-survivors

From: Interstitial lung disease in clinically amyopathic dermatomyositis with and without anti-MDA-5 antibody: to lump or split?

  Survivors Non-survivors p value
(n = 4) (n = 6)
Gender (male/female) 2/2 4/2 1.00
Age 58.5 (47.8–64.3) 63.0 (59.3–64.5) 0.519
Time
 from onset to first visit 29.5 (26.0–50.3) 11.0 (11.0–13.3) 0.0666
 from onset to treatment initiation 68.5 (31.5–107) 16.0 (12.8–23.0) 0.0381
Symptoms and signs
 Gottron’s sign 2 (50 %) 5 (83 %) 0.500
 Heliotrope eruption 2 (50 %) 5 (83 %) 0.500
 V/shawl neck sign 1 (25 %) 4 (67 %) 0.524
 Mechanic’s hands 0 2 (33 %) 0.467
 Palmar erythema 0 2 (33 %) 0.467
 Myalgia 2 (50 %) 1 (17 %) 0.500
 Cough 4 (100 %) 1 (17 %) 0.0480
 Dyspnea on exertion 3 (75 %) 2 (33 %) 0.524
 Fever 3 (75 %) 6 (100 %) 0.200
Laboratory data
 Aspartate aminotransferase 55.5 (36.8–76.8) 55.5 (41.0–110) 0.762
 γ-glutamyl transpeptidase 53.5 (43.5–57.5) 28.0 (23.0–110) 0.914
 Krebs von den Lungen-6 1135 (930–1190) 524 (470–626) 0.114
 Surfactant protein D 45.3 (23.7–75.8) 32.5 (24.2–40.9) 0.669
Bronchoalveolar lavage
 CD4+/CD8+ ratio 3.52 (2.12–4.04) 1.47 (1.20–2.19) 0.857
HRCT findings
  Consolidation 1 (25 %) 0 0.400
  Ground glass opacity 0 5 (83 %) 0.0480
  Reticulation 1 (25 %) 0 1.00
  Irregular linear opacity 2 (50 %) 1 (17 %) 0.500
  1. Categorical data are presented as numbers (percentages) and were analyzed using Fisher’s exact test. Continuous data are presented as medians (interquartile ranges) and were analyzed using the Mann–Whitney U test. A p value of <0.05 was considered statistically significant
  2. Abbreviations: HRCT high-resolution computed tomography, MDA-5, anti-melanoma differentiation-associated gene 5