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Table 1 Baseline demographics of adult cystic fibrosis patients with known S. pyogenes Sputum isolates

From: Clinical implications and characterization of Group A Streptoccoccus infections in adults with cystic fibrosis

Patient

Agea

Sex

Mutation 1

Mutation 2

Pancreatic Status

Current Smoker

Baseline FEV1 (L)b (% predicted)

Baseline FVC (L)c (% predicted)

TISd

AZMe

LABAf

ICSg

CFh

Co-morbidities

1

19

M

F508del

F508del

I

N

2.62 (74)

4.09(100)

Y

N

N

N

DIOS, B

2

19

M

F508del

3849+1G->A

I

N

3.07 (71)

-

N

N

N

N

Liver, S

3

34

M

F508del

E56K

S

N

3.87 (106)

4.98(115)

N

N

N

N

None

4

18

F

M1101K

M1101K

I

N

2.22 (71)

3.06(93)

Y

N

N

N

 

5

24

F

F508del

F508del

I

Unknown

1.19 (35)

1.84(47)

N

N

N

N

DIOS

6

28

F

F508del

F508del

I

N

2.39 (89)

3.72(122)

N

N

N

N

IGT,DIOS

7

38

F

F508del

R347H

S

Unknown

2.15 (77)

3.14(95)

N

N

N

N

S

8

48

M

F508del

F508del

I

N

2.30 (54)

4.79(90)

Y

Y

Y

N

IGT

9

19

M

1717-1G->A

Unknown

S

N

3.73 (82)

4.55(85)

N

N

N

N

S

10

21

M

F508del

F508del

I

Y

2.63 (40)

3.61(84)

N

N

N

N

DIOS

11

33

F

F508del

R334W

I

N

1.11 (71)

2.34(74)

N

N

N

N

DIOS

12

26

M

G542x

Unknown

I

Y

2.96 (69)

4.99(100)

N

Y

Y

N

CFRD

13

26

F

Unknown

Unknown

I

N

2.80 (88)

4.10(108)

Y

N

N

N

CFRD,B, S, DIOS,

14

24

M

F508del

F508del

I

N

3.84 (84)

5.80(115)

Y

N

N

Y

Liver

15

28

F

M1101K

M1101K

I

N

2.67 (91)

3.37 (101)

N

N

N

N

B,S

  1. I insufficient, S sufficient, Y yes, N no
  2. a Age at time of first S. pyogenes isolation.
  3. b Baseline FEV 1 forced expiratory volume in one second recorded 2 years prior to the index GAS isolate
  4. c Baseline FVC forced volume capacity recorded 2 years prior to the index GAS isolate
  5. d TIS Chronic inhaled tobramycin therapy
  6. e AZM Chronic azithromycin
  7. f LABA Long-acting beta agonist
  8. g ICS Inhaled corticosteroid
  9. h CF Comorbidities, DIOS Distal Ileal Obstruction Syndrome, B osteoporosis, Liver liver disease, S sinus disease, IGT Impaired Glucose Tolerance, CFRD CF related diabetes