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Table 10 Healthcare resource utilization outcomes in the subsequent period

From: Change in forced vital capacity and associated subsequent outcomes in patients with newly diagnosed idiopathic pulmonary fibrosis

  By lung-function change category (based on relative change in FVC%)a
  All Patients Stable or Marginal (Δ < 10 %) [A] Significant (Δ ≥ 10 %) [B] Relative Effect Measure (95 % CI)
  (N = 490) (N = 348) (N = 142) [B] vs. [A]
Subsequent Period     
  12-Month IR per Patient IRR
Rate of IPF-related outpatient visits 2.39 2.34 2.56 1.09 (0.91–1.32)
 Unscheduled and/or urgent care 0.30 0.24 0.55 2.25 (1.45–3.50)
 For a suspected AEx 0.30 0.24 0.54 2.28 (1.47–3.51)
Rate of outpatient visits indicating that the following medications/treatments were prescribed for IPF
 Prednisone 1.22 1.09 1.60 1.47 (1.16–1.85)
 Azathioprine 0.39 0.34 0.54 1.57 (0.96–2.57)
 N-acetylcysteine 0.70 0.67 0.79 1.19 (0.85–1.67)
Rate of outpatient visits that included the following tests/procedures
 Arterial blood gas test 0.25 0.19 0.35 1.80 (0.90–3.60)
 High-resolution computed tomography 0.29 0.27 0.36 1.32 (0.75–2.33)
 Chest X-ray 0.55 0.54 0.60 1.11 (0.77–1.59)
 Lung biopsy 0.03 0.03 0.01 0.39 (0.05–3.44)
 Pulmonary rehabilitation 0.21 0.19 0.26 1.40 (0.86–2.27)
Rate of IPF-related ER visits 0.43 0.41 0.53 1.30 (0.80–2.12)
 For a suspected AEx 0.19 0.16 0.29 1.84 (1.04–3.27)
Rate of ER visits that included the following tests/procedures
 Arterial blood gas test 0.24 0.21 0.34 1.63 (0.95–2.81)
 High-resolution computed tomography 0.14 0.12 0.20 1.71 (0.88–3.30)
 Chest X-ray 0.24 0.22 0.30 1.36 (0.79–2.32)
 Supplemental oxygen therapy 0.21 0.18 0.29 1.58 (0.89–2.79)
Rate of IFP-related hospitalizations 0.34 0.26 0.61 2.31 (1.10–4.85)
 For a suspected AEx 0.20 0.13 0.43 3.46 (2.00–5.98)
 Rate of hospital days not for a suspected AEx 0.53 0.44 0.81 1.84 (0.38–9.07)
 Rate of hospital days for a suspected AEx 2.06 1.07 4.50 4.19 (1.69–10.41)
 Rate of ICU stays 0.13 0.09 0.28 3.07 (1.38–6.83)
 Rate of ICU days 0.62 0.42 1.22 2.92 (1.12–7.63)
Rate of hospitalizations that included the following tests/procedures
 Arterial blood gas test 0.18 0.12 0.36 2.87 (1.48–5.54)
 Mechanical ventilation 0.08 0.07 0.16 2.47 (0.85–7.12)
 Non-invasive ventilation 0.08 0.04 0.20 5.50 (2.90–10.45)
 Supplemental oxygen therapy 0.13 0.09 0.28 3.22 (1.69–6.17)
  1. IR Incidence rate, IRR Incidence rate ratio
  2. aLung-function change categories were defined as the relative change in FVC% from index to approximately 6 months following IPF diagnosis. "Stable or Marginal" was defined as decline less than 10 %, while "Significant" was defined as decline greater than or equal to 10 %
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BMC Pulmonary Medicine

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