By lung-function change category (based on relative change in FVC%)a | ||||||
---|---|---|---|---|---|---|
Stable [A] | Marginal [B] | Significant [C] | P-value* | |||
(N = 250) | (N = 98) | (N = 142) | [C] vs. [A] | [C] vs. [A] | [C] vs. [A] | |
Comorbidities, N (%)b | ||||||
Gastroesophageal reflux disease | 82 (32.8 %) | 26 (26.5 %) | 45 (31.7 %) | 0.999 | 0.999 | 0.999 |
Cardiac disorder | 43 (17.2 %) | 28 (28.6 %) | 34 (23.9 %) | 0.260 | 0.999 | 0.053 |
Metabolic disorder | 38 (15.2 %) | 20 (20.4 %) | 29 (20.4 %) | 0.500 | 0.999 | 0.642 |
Other vascular disorder | 32 (12.8 %) | 23 (23.5 %) | 27 (19.0 %) | 0.300 | 0.999 | 0.069 |
Pulmonary hypertension | 31 (12.4 %) | 20 (20.4 %) | 16 (11.3 %) | 0.999 | 0.095 | 0.198 |
Emphysema | 18 (7.2 %) | 8 (8.2 %) | 15 (10.6 %) | 0.783 | 0.999 | 0.999 |
Other pulmonary disorder | 14 (5.6 %) | 7 (7.1 %) | 13 (9.2 %) | 0.435 | 0.999 | 0.999 |
Symptoms at IPF diagnosis, N (%)b | ||||||
Dyspnea/shortness of breath | 209 (83.6 %) | 88 (89.8 %) | 132 (93.0 %) | 0.030* | 0.999 | 0.668 |
Cough | 175 (70.0 %) | 71 (72.4 %) | 110 (77.5 %) | 0.428 | 0.999 | 0.999 |
Fatigue or malaise | 107 (42.8 %) | 47 (48.0 %) | 78 (54.9 %) | 0.145 | 0.999 | 0.999 |
Rapid, shallow breathing | 25 (10.0 %) | 11 (11.2 %) | 14 (9.9 %) | 0.999 | 0.999 | 0.999 |
Gradual, unintended weight loss | 17 (6.8 %) | 9 (9.2 %) | 24 (16.9 %) | 0.035* | 0.317 | 0.999 |
Clubbing | 14 (5.6 %) | 11 (11.2 %) | 17 (12.0 %) | 0.309 | 0.999 | 0.321 |
Other | 1 (0.4 %) | 0 (0.0 %) | 2 (1.4 %) | - | - | - |
GAP index, mean (SD)c | 3.3 (1.5) | 3.5 (1.5) | 3.7 (1.4) | 0.149 | 0.999 | 0.774 |
Lung-function measures at IPF diagnosis, mean [median] (SD) | ||||||
FVC (liters) | 2.6 (1.1) | 2.4 (0.9) | 2.4 (1.0) | 0.821 | 0.999 | 0.796 |
FVC% | 61.7 %(26.1 %) | 58.5 % (24.0 %) | 59.5 % (27.6 %) | 0.999 | 0.999 | 0.999 |
FEV1 (liters) | 2.0 (0.9) | 1.8 (0.7) | 1.7 (0.6) | 0.021* | 0.901 | 0.395 |
FEV1/FVC | 79.6 % (12.6 %) | 79.9 % (11.8 %) | 80.7 % (12.5 %) | 0.999 | 0.999 | 0.999 |
DLCO percent predicted | 53.4 % (14.4 %) | 51.2 % (16.1 %) | 47.7 % (16.5 %) | 0.033* | 0.583 | 0.962 |