| |
By lung-function change category (based on relative change in FVC%)a
|
|---|
| |
Stable [A]
|
Marginal [B]
|
Significant [C]
|
Relative effect measure (95 % CI)
|
|---|
|
(N = 250)
|
(N = 98)
|
(N = 142)
|
[C] vs. [A]
|
[C] vs. [B]
|
[B] vs. [A]
|
|---|
| |
6-Month IR per Patient
|
IRR
|
|
Rate of suspected AEx
|
0.21
|
0.25
|
0.25
|
1.20 (0.69–2.09)
|
1.00 (0.55–1.82)
|
1.20 (0.63–2.28)
|
| |
6-Month Risk
|
OR
|
|
Risk of suspected AEx
|
14.1 %
|
16.7 %
|
20.4 %
|
1.56 (0.78–3.15)
|
1.27 (0.56–2.91)
|
1.23 (0.56–2.70)
|
|
Risk of progression
|
23.4 %
|
38.7 %
|
48.6 %
|
3.09 (1.67–5.72)
|
1.50 (0.75–3.00)
|
2.07 (1.07–3.97)
|
| |
6-Month IR per Patient
|
IRR
|
|
Rate of IPF-related outpatient visits
|
1.85
|
1.95
|
1.78
|
0.96 (0.82–1.12)
|
0.91 (0.75–1.12)
|
1.05 (0.87–1.27)
|
|
Unscheduled and/or urgent care
|
0.16
|
0.23
|
0.22
|
1.42 (0.64–3.15)
|
0.97 (0.48–1.96)
|
1.46 (0.76–2.80)
|
|
For a suspected AEx
|
0.17
|
0.19
|
0.19
|
1.16 (0.58–2.31)
|
1.04 (0.52–2.09)
|
1.11 (0.54–2.29)
|
|
Rate of IPF-related ER visits
|
0.18
|
0.16
|
0.14
|
0.81 (0.31–2.11)
|
0.87 (0.37–2.01)
|
0.94 (0.40–2.17)
|
|
For a suspected AEx
|
0.04
|
0.02
|
0.05
|
1.15 (0.34–3.86)
|
2.46 (0.41–14.72)
|
0.47 (0.07–3.17)
|
|
Rate of IPF-related hospitalizations
|
0.06
|
0.08
|
0.05
|
0.80 (0.20–3.12)
|
0.59 (0.17–1.98)
|
1.36 (0.35–5.20)
|
|
For a suspected AEx
|
0.04
|
0.06
|
0.04
|
0.96 (0.19–4.82)
|
0.63 (0.17–2.32)
|
1.52 (0.27–8.60)
|
|
Rate of hospital days
|
0.39
|
0.48
|
0.25
|
0.63 (0.10–3.82)
|
0.52 (0.10–2.62)
|
1.22 (0.28–5.26)
|
|
Rate of ICU stays
|
0.03
|
0.03
|
0.02
|
0.59 (0.07–4.97)
|
0.47 (0.07–2.95)
|
1.25 (0.21–7.58)
|
|
Rate of ICU days
|
0.08
|
0.18
|
0.07
|
0.79 (0.05–12.62)
|
0.36 (0.03–4.05)
|
2.16 (0.23–20.59)
|
-
AEx Acute exacerbation, IR incidence rate, IRR incidence rate ratio, OR odds ratio
-
aLung-function change categories were defined as the relative change in FVC% from index to approximately 6 months following IPF diagnosis. "Stable" was defined as decline <5 %. "Marginal" was defined as decline ≥5 % and <10 %, while "Significant" was defined as decline ≥10 %
