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Table 3 Clinical characteristics and healthcare resource utilization in the concurrent period by FVC% change group

From: Change in forced vital capacity and associated subsequent outcomes in patients with newly diagnosed idiopathic pulmonary fibrosis

  By lung-function change category (based on relative change in FVC%)a
  Stable [A] Marginal [B] Significant [C] Relative effect measure (95 % CI)
(N = 250) (N = 98) (N = 142) [C] vs. [A] [C] vs. [B] [B] vs. [A]
  6-Month IR per Patient IRR
Rate of suspected AEx 0.21 0.25 0.25 1.20 (0.69–2.09) 1.00 (0.55–1.82) 1.20 (0.63–2.28)
  6-Month Risk OR
Risk of suspected AEx 14.1 % 16.7 % 20.4 % 1.56 (0.78–3.15) 1.27 (0.56–2.91) 1.23 (0.56–2.70)
Risk of progression 23.4 % 38.7 % 48.6 % 3.09 (1.67–5.72) 1.50 (0.75–3.00) 2.07 (1.07–3.97)
  6-Month IR per Patient IRR
Rate of IPF-related outpatient visits 1.85 1.95 1.78 0.96 (0.82–1.12) 0.91 (0.75–1.12) 1.05 (0.87–1.27)
 Unscheduled and/or urgent care 0.16 0.23 0.22 1.42 (0.64–3.15) 0.97 (0.48–1.96) 1.46 (0.76–2.80)
 For a suspected AEx 0.17 0.19 0.19 1.16 (0.58–2.31) 1.04 (0.52–2.09) 1.11 (0.54–2.29)
Rate of IPF-related ER visits 0.18 0.16 0.14 0.81 (0.31–2.11) 0.87 (0.37–2.01) 0.94 (0.40–2.17)
 For a suspected AEx 0.04 0.02 0.05 1.15 (0.34–3.86) 2.46 (0.41–14.72) 0.47 (0.07–3.17)
Rate of IPF-related hospitalizations 0.06 0.08 0.05 0.80 (0.20–3.12) 0.59 (0.17–1.98) 1.36 (0.35–5.20)
 For a suspected AEx 0.04 0.06 0.04 0.96 (0.19–4.82) 0.63 (0.17–2.32) 1.52 (0.27–8.60)
 Rate of hospital days 0.39 0.48 0.25 0.63 (0.10–3.82) 0.52 (0.10–2.62) 1.22 (0.28–5.26)
 Rate of ICU stays 0.03 0.03 0.02 0.59 (0.07–4.97) 0.47 (0.07–2.95) 1.25 (0.21–7.58)
 Rate of ICU days 0.08 0.18 0.07 0.79 (0.05–12.62) 0.36 (0.03–4.05) 2.16 (0.23–20.59)
  1. AEx Acute exacerbation, IR incidence rate, IRR incidence rate ratio, OR odds ratio
  2. aLung-function change categories were defined as the relative change in FVC% from index to approximately 6 months following IPF diagnosis. "Stable" was defined as decline <5 %. "Marginal" was defined as decline ≥5 % and <10 %, while "Significant" was defined as decline ≥10 %