Fig. 4From: Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational studyChanges in haemodynamic parameters and 6-minute-walk distance over the study (intra-individual responses). (a–c) Pulmonary arterial pressure (PAP), (d–f) cardiac output, (g–i) pulmonary vascular resistance (PVR), and (j–l) 6-minute-walk distance (6MWD). Data are presented as means ± 95 % confidence interval. Patients were treated with iloprost followed by addition of sildenafil (iloprost/sildenafil), sildenafil followed by addition of iloprost (sildenafil/iloprost), or upfront combination therapy with iloprost and sildenafil (iloprost + sildenafil). Values are shown pre-treatment (baseline), 3 months after therapy initiation (monotherapy), before combination therapy (post-monotherapy baseline), and 3 months after starting combination therapy (combined therapy). *P < 0.05; **P < 0.01; ***P < 0.001. Statistical analysis was conducted using the paired sample t-test (two-tailed)Back to article page