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Table 4 Nurse-observed, definitely serious errors for Diskus vs. Pulmojet and Turbohaler vs. Pulmojet comparisons: post-patient information leaflet alone and post-leaflet and instructional video (post-hoc sensitivity analysis)

From: Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study

 

First randomised device

Non-inferiority

Superiority

Pulmojet vs. Diskus

Pulmojet

Diskus

Proportions of patients with no errors: Difference (95 % CI)

Serious error with Pulmojeta relative to comparator (1.00): Odds ratio (95 % CI)

p-value a

 

(n = 277)

(n = 277)

   

Post-patient information leaflet alone

No definitely serious error, n (%)

147 (53.1)

129 (46.6)

0.06 (−0.02 to 0.15)

--

--

≥1 errors, n (%)

130 (46.9)

148 (53.4)

--

0.74 (0.51–1.06)

0.099

Post-patient information leaflet and instructional video

No definitely serious error, n (%)

229 (82.7)

206 (74.4)

0.08 (0.01–0.15)

--

--

≥1 errors, n (%)

48 (17.3)

71 (25.6)

--

0.45 (0.26–0.78)

0.004

Pulmojet vs. Turbohaler

Pulmojet (n = 144)

Turbohaler (n = 144)

   

Post-patient information leaflet alone

No definitely serious error, n (%)

78 (54.2)

44 (30.6)

0.24 (0.13–0.35)

--

--

≥1 errors, n (%)

66 (45.8)

100 (69.4)

--

0.26 (0.14–0.49)

<0.001

Post-patient information leaflet and instructional video

No definitely serious error, n (%)

115 (79.9)

85 (59.0)

0.21 (0.10–0.31)

--

--

≥1 errors, n (%)

29 (20.1)

59 (41.0)

--

0.32 (0.17–0.58)

<0.001

  1. aConditional logistic regression