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Table 2 Characteristics of variability of oxygen uptake (V̇O2) measurements during 129 biological quality control tests, using three different quality control methods

From: Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials

Variable

Work rate (W)

Number (% of all tests)

Mean ± SD (% predicted)

Median (% predicted)

Coefficient of variation (%)

Normality (Shapiro–Wilk)

V̇O2 at 20 W

 All tests

20

129 (100)

92.1 ± 12.2

93.5

14.3

Passed

 Criteriona

20

43 (33)

96.1 ± 5.4

94.8

5.6

P < 0.001

 Readerb

20

98 (76)

91.9 ± 11.5d

93.1

12.5

Passed

 Composite z-scorec

20

62 (48)

95.8 ± 5.9

95.0

6.2

Passed

V̇O2 at 70 W

 All tests

70

129 (100)

97.5 ± 11.0

97.7

11.3

Passed

 Criteriona

70

43 (33)

98.4 ± 4.1

98.1

4.2

Passed

 Readerb

70

98 (76)

97.6 ± 9.4

97.1

9.6

Passed

 Composite z-scorec

70

62 (48)

99.0 ± 4.6

98.4

4.7

Passed

∆V̇O2/∆WR

 All tests

∆50

129 (100)

105.7 ± 13.6

105.8

12.9

P = 0.006

 Criteriona

∆50

43 (33)

102.0 ± 5.4

102.5

5.3

Passed

 Readerb

∆50

98 (76)

106.3 ± 11.4

105.1

10.7

P < 0.001

 Composite z-scorec

∆50

62 (48)

103.9 ± 6.2

104.3

6.0

Passed

  1. SD standard deviation, V̇O 2 oxygen uptake, V̇CO 2 carbon dioxide output, V̇E minute ventilation, ∆V̇O 2 /∆WR “functional gain” or the increase in V̇O2 per W
  2. aCriterion method was based on V̇O2,20W, V̇O2,70W and V̇O2,slope being within ±10 % predicted
  3. bReader method was based on V̇O2, V̇CO2, and V̇E within ±10 % of the initial value
  4. cComposite z-score of 0.67, based on deviation of V̇O2,70W and V̇O2,slope from predicted, with knowledge of SD from all BioQC tests
  5. d P < 0.05 Student–Newman–Keuls multiple comparison test within the V̇O2 at 20 W