Table 1 General characteristics of 17 patients with IgG4-related lung disease
Number (%) or mean (range) | |
|---|---|
Male : Female | 1 : 1.83 |
Age (years) | 44.8 ± 15.0 (18–71) |
History of smoking | 4/17 (23.5 %) |
Comorbidity | |
Allergy | 3/17 |
Primary Sjogren syndrome | 2/17 |
Healed pulmonary tuberculosis | 2/17 |
Chronic gastritis | 1/17 |
Diabetes mellitus | 1/17 |
Obstructive pulmonary disease | 1/17 |
Asthma | 1/17 |
Vitiligo | 1/17 |
Psoriasis | 1/17 |
Hypertension | 1/17 |
Clinical symptoms | |
Cough | 11/17 (64.7 %) |
Fever | 7/17 (41.2 %) |
Dyspnea | 5/17 (29.4 %) |
Chest pain | 4/17 (23.5 %) |
Hemoptysis | 2/17 (11.8 %) |
Asymptomatic | 2/17 (11.8 %) |
Laboratory findings | |
White blood cell count > 10 × 109/L | 7/17 (41.2 %) |
ESR > 20 mm/h | 11/17 (64.7 %) |
CRP > 5 mg/L | 8/17 (47.1 %) |
IgG > 17 g/L | 11/15 (73.3 %) |
IgG4 > 1350 mg/L | 7/13 (53.8 %) |
IgG4/IgG > 8 % | 5/13 (38.5 %) |
tIgE > 100 IU/mL | 5/8 (62.5 %) |
ANA ≥ 1:80 | 3/16 (18.8 %) |
Chest CT findings | |
Nodules and masses with spiculated borders | 8/17 (47.1 %) |
Alveolar consolidations with air bronchograms | 5/17 (29.4 %) |
Ground glass opacities ± reticular opacities | 6/17 (35.3 %) |
Hilar or mediastinal lymphadenopathy | 5/17 (29.4 %) |
Thickening of the bronchovasular bundles | 2/17 (11.8 %) |
Thickening of the interlobular septa | 2/17 (11.8 %) |
Pulmonary function test | |
FEV1/FVC < 70 % | 1/9 (11.1 %) |
TLC% < 80 % | 3/7 (42.9 %) |
DLCO% < 80 % | 8/8 (100 %) |